언어 선택

SIRP alpha

SIRP alpha 분자 정보

영어 이름	Signal-regulatory protein alpha	시판 약물 수	2
임상 약물 수	19	표적 별명	SHPS-1，Macrophage fusion receptor，Brain Ig-like molecule with tyrosine-based activation motifs，MFR，Signal-regulatory protein alpha-1，Signal-regulatory protein alpha-2，CD172a，MyD-1 antigen，Sirp-alpha-3，MYD1，SIRPA，Signal Regulatory Protein Alpha，CD172 Antigen-Like Family Member A，Inhibitory Receptor SHPS-1，PTPNS1，SHPS1，SIRP，P84，Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs，Protein Tyrosine Phosphatase， Non-Receptor Type Substrate 1，Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1，Tyrosine Phosphatase SHP Substrate 1，Signal-Regulatory Protein Alpha-3，Signal-Regulatory Protein Alpha，SHP Substrate 1，CD172a Antigen，Sirp-Alpha-1，Sirp-Alpha-2，MYD-1，Bit，SIRPalpha，SIRPalpha2
최고 연구 개발 단계	Approved

영어 이름	Signal-regulatory protein alpha
표적 별명	SHPS-1，Macrophage fusion receptor，Brain Ig-like molecule with tyrosine-based activation motifs，MFR，Signal-regulatory protein alpha-1，Signal-regulatory protein alpha-2，CD172a，MyD-1 antigen，Sirp-alpha-3，MYD1，SIRPA，Signal Regulatory Protein Alpha，CD172 Antigen-Like Family Member A，Inhibitory Receptor SHPS-1，PTPNS1，SHPS1，SIRP，P84，Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs，Protein Tyrosine Phosphatase， Non-Receptor Type Substrate 1，Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1，Tyrosine Phosphatase SHP Substrate 1，Signal-Regulatory Protein Alpha-3，Signal-Regulatory Protein Alpha，SHP Substrate 1，CD172a Antigen，Sirp-Alpha-1，Sirp-Alpha-2，MYD-1，Bit，SIRPalpha，SIRPalpha2
시판 약물 수	2
임상 약물 수	19
최고 연구 개발 단계	Approved

SIRP alpha 제품 목록

속성
Protein (19)Cell (1)
제품 라이브러리
온라인 (20)
종
Human (9)Mouse (6)Cynomolgus (4)Rat (1)
태그
Fc Tag (5)Mouse IgG Fc Tag (2)His Tag (4)Fc Tag & Avi Tag (3)His Tag & Avi Tag (3)Mouse IgG Fc Tag & Avi Tag (1)Llama IgG Fc Tag (1)- (1)
마커
Unconjugated (10)Biotin-labeled (7)PE Labeled (2)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT SIA-H5225	Human	HEK293	Human SIRP alpha / CD172a Protein, His Tag, low endotoxin (MALS & BLI verified)
HOT SIA-H82A3	Human	HEK293	Biotinylated Human SIRP alpha / CD172a Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
HOT SIA-H82E0	Human	HEK293	Biotinylated Human SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
HOT SIA-HP252	Human	HEK293	PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay) (Site-specific conjugation)
HOT SIA-M52H4	Mouse	HEK293	Mouse SIRP alpha / CD172a Protein, His Tag (MALS verified)
CDA-H82F2	Human	HEK293	Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
CHEK-ATP051	Human	HEK293	HEK293/Human SIRP alpha Stable Cell Line
SIA-H5251	Human	HEK293	Human SIRP alpha / CD172a Protein, Fc Tag, low endotoxin (MALS verified)
SIA-H5258	Human	HEK293	Human SIRP alpha / CD172a (31-149) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
SIA-H52A8	Human	HEK293	Human SIRP alpha / CD172a Protein, Mouse IgG1 Fc Tag, low endotoxin (MALS verified)

총 수량20

SIRP alpha분자 배경

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alpha분자 별명

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Ipsoprubart	ELA-026	Phase 3 Clinical	Electra Therapeutics Inc	Lymphohistiocytosis, Hemophagocytic; Neoplasms	상세
LM-101	LM-101	Phase 2 Clinical	LaNova Medicines Ltd	Hematologic Neoplasms; Leukemia; Neoplasms; Solid tumours	상세
HX-044	HX044; HX-044	Phase 2 Clinical	Hanx Biopharmaceuticals Pty Ltd	Lymphoma; Solid tumours	상세
BRB-002	BRB-002	Phase 2 Clinical	Bitterroot Bio Inc	Atherosclerosis; Cardiovascular Diseases; Vasculitis	상세
BI-770371	BI-770371	Phase 2 Clinical	Ose Immunotherapeutics	Carcinoma, Non-Small-Cell Lung; Liver Cirrhosis; Melanoma; Metabolic Dysfunction-Associated Steatotic Liver Disease; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
IBC-0966	IBC-0966	Phase 2 Clinical		Neoplasms	상세
HX-009	HX-009; HX009-II-02	Phase 2 Clinical	Waterstone Hanxbio Pty Ltd	Bile Duct Neoplasms; Biliary Tract Neoplasms; Liver Neoplasms; Lymphoma; Melanoma; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
BI-765063	OSE-172; BI-765063; Effi-DEM	Phase 1 Clinical	Effimune	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
ADU-1805	ADU-1805	Phase 1 Clinical	Aduro Biotech Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Solid tumours	상세
Q-1801	Q-1801; Q 1801	Phase 1 Clinical	Qure Biotechnology (Shanghai) Co Ltd	Solid tumours	상세
Recombinant humanized IgG4 anti-SIRPα antibody（Daiichi Sankyo）	DS-1103a	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Breast Neoplasms; Solid tumours	상세
JY-47	JY47; JY-47	Phase 1 Clinical	Hangzhou Jiuyuan Gene Biomedical Co Ltd	Liver Cirrhosis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Solid tumours	상세
BYON-4228	BYON-4228	Phase 1 Clinical	Sanquin Blood Supply Foundation	Lymphoma; Solid tumours	상세
BSI-082	BSI-082	Phase 1 Clinical	Biosion Inc	Hematologic Neoplasms; Neoplasm Metastasis; Solid tumours	상세
BR-105	BR-105; BR105	Phase 1 Clinical	Hisun Biopharmaceutical Co Ltd, Zhejiang BioRay Biopharmaceuticals Co Ltd	Lymphoma, Large B-Cell, Diffuse; Neoplasms	상세
[89Zr]Zr- BI-765063(Boehringer Ingelheim)		Phase 1 Clinical	Boehringer Ingelheim Corp	Carcinoma, Non-Small-Cell Lung; Melanoma; Squamous Cell Carcinoma of Head and Neck	상세
TQB-2928	TQB-2928	Phase 1 Clinical	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms; Osteosarcoma; Solid tumours	상세
BI-765080		Phase 1 Clinical	C.H. Boehringer Sohn Ag & Co. Kg		상세
ES-004	ES-004; ES 004-N4; ES 004-B4	Phase 1 Clinical	Elpiscience (Shanghai) Biopharma Ltd	Neoplasms; Solid tumours	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Relugolix/Estradiol/Norethindrone Acetate	E2/NETA	Approved	Myovant Sciences	MYFEMBREE, RYEQO	United States	Menorrhagia; Leiomyoma	Sumitomo Pharma America Inc, Myovant Sciences	2021-05-26	Endometriosis; Leiomyoma; Menorrhagia; Pain; Uterine Neoplasms	상세
Elagolix/estradiol/norethindrone acetate		Approved	Abbvie Inc	Oriahnn	United States	Menorrhagia	Abbvie Inc	2020-05-29	Menorrhagia	상세

제품 리뷰

R***n2024-06-03
0사람들이 좋아합니다
PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay) (Site-specific conjugation)
I recently used the PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag for detecting the expression of CD47 in Jurkat T-cells and primary T-cells, and I am very pleased with the results. The SIRP alpha reagent effectively binds to CD47 overexpressed in both Jurkat and primary T-cells. This experiment was conducted to demonstrate the overexpression of CD47 in T-cells, using the anti-CD47 antibody (clone: CC2C6) to confirm the expression. Additionally, it was crucial to show that our CD47 can bind to its natural ligand, SIRP alpha. The reagent performed excellently in this regard, providing clear and reliable results. I've attached an image showing the data with a CD47 KO Jurkat cell line, further validating the specificity and effectiveness of this reagent. Overall, I highly recommend this product for CD47 detection and binding studies.
J***r2022-08-18
0사람들이 좋아합니다
PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay) (Site-specific conjugation)
I used this SIRPa-PE Fc tag for a FACS assay using the recommended SOP provided by Acro and our rep Nik Kamachi. Nik was very helpful in providing insight on the capabilities of Acro to provide custom labeled SIRPa Fc tags to meet our needs for small molecule screening assays that are FACS and IF-based. The human SIRPa-PE Fc tag was very easy to use and gave a strong signal with both flow cytometry and imaging
M***g2022-05-07
1사람들이 좋아합니다
Human SIRP alpha / CD172a Protein, Fc Tag, low endotoxin (MALS verified)
We purchased the SIRP-alpha-Fc protein for CD47 competition studies via BLI. The protein was delivered quickly and easy to resuspend following the instructions in the COA. We observed strong binding for this protein to CD47 and minimal background binding to the sensors. We were also able to demonstrate competition with commercially available antibodies. Overall, this product specifically binds CD47 and worked well in BLI based competition assays.