언어 선택

Siglec-8

Siglec-8 분자 정보

영어 이름	Sialic acid-binding Ig-like lectin 8	시판 약물 수	0
임상 약물 수	1	표적 별명	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
최고 연구 개발 단계	Phase 3 Clinical

영어 이름	Sialic acid-binding Ig-like lectin 8
표적 별명	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 3 Clinical

Siglec-8 제품 목록

속성
Protein (3)
제품 라이브러리
온라인 (3)
종
Human (3)
태그
His Tag (1)Fc Tag (1)His Tag & Avi Tag (1)
마커
Unconjugated (2)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT SI8-H52H8	Human	HEK293	Human Siglec-8 Protein, His Tag, low endotoxin (MALS verified)
SI8-H5254	Human	HEK293	Human Siglec-8 Protein, Fc Tag
SI8-H82E9	Human	HEK293	Biotinylated Human Siglec-8 Protein, His,Avitag™

총 수량3

Siglec-8분자 배경

Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8분자 별명

Siglec-8,SAF-2,SIGLEC8,SAF2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
AK-001	AK-001	Phase 3 Clinical	Allakos Inc	Community Acquired Pneumonia; Hypersensitivity; Nasal Polyps; Respiratory Tract Infections; Urinary Tract Infections	상세