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Siglec-6

Siglec-6 Overview

English Name	Sialic acid-binding Ig-like lectin 6	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	CD33 antigen-like 1，CDw327，Obesity-binding protein 1 (OB-BP1)，OBBP1，CD33L，CD33L1，CD327
Highest Development Stage	Phase 2 Clinical

English Name	Sialic acid-binding Ig-like lectin 6
Target Synonym	CD33 antigen-like 1，CDw327，Obesity-binding protein 1 (OB-BP1)，OBBP1，CD33L，CD33L1，CD327
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

Siglec-6 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Fc Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
SI6-H5256	Human	HEK293	Human Siglec-6 / CD327 Protein, Fc Tag, low endotoxin

Total: 1

Siglec-6 Background

Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Siglec-6 Synonyms

SIGLEC6,CD327,CD33L,CD33L1,OBBP1,OB-BP1,CDw327

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
anti-siglec-6 CAR-T cell therapy(Xuzhou Medical University)		Phase 2 Clinical	Xuzhou Medical University (Xzmu)	Leukemia, Myeloid, Acute	Details
AK-006	AK006	Phase 1 Clinical	Allakos Inc	Chronic Urticaria; Inflammation	Details

Product Reviews

C***u2022-06-25
0People Like
Human Siglec-6 / CD327 Protein, Fc Tag, low endotoxin
The item was expedited very quickly which worked out with our timeline. We are in the process of using the Siglec-6 protein in one of our in-vivo study for immunization. The material itself did not dissolve in complete freund's adjuvant but it was easily made into a fine suspension with the help of some PBS. Overall, I would say the material is easy to work with and the Acro is quick at responding if we have any issues.