Siglec-15
Siglec-15 분자 정보
| 영어 이름 | Sialic acid-binding Ig-like lectin 15 | 시판 약물 수 | 0 |
| 임상 약물 수 | 3 | 표적 별명 | SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15 |
| 최고 연구 개발 단계 | Phase 2 Clinical | ||
| 영어 이름 | Sialic acid-binding Ig-like lectin 15 |
| 표적 별명 | SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15 |
| 시판 약물 수 | 0 |
| 임상 약물 수 | 3 |
| 최고 연구 개발 단계 | Phase 2 Clinical |
Siglec-15 제품 목록
- 속성
Protein (7)
- 제품 라이브러리
온라인 (7)
- 종
Human (4)Rhesus macaque (1)Mouse (1)Rat (1)
- 태그
Fc Tag (1)His Tag (4)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
- 마커
Unconjugated (5)Biotin-labeled (2)
| 제품 번호 | 종 | 발현 시스템 | 제품 설명 | 단백질 구조 | 순도 | 특성 |
|---|---|---|---|---|---|---|
 Human | HEK293 | Human Siglec-15 / CD33L3 Protein, Fc Tag |  |  |  | |
HOT SG5-H52H3 | Human | HEK293 | Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified) |  | | |
HOT SG5-H82E9 | Human | HEK293 | Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning) |  | | |
| Human | HEK293 | Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™ |  | | | |
 Mouse | HEK293 | Mouse Siglec-15 / CD33L3 Protein, His Tag |  | | | |
 Rhesus macaque | HEK293 | Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag |  | | | |
 Rat | HEK293 | Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified) |  | | |
총 수량7
- 1
Siglec-15분자 배경
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Siglec-15분자 별명
CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15
임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| NC-318 | NC-318; 5G-12 | Phase 2 Clinical | Yale School Of Medicine | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Lung Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck | 상세 |
| DS-1501 | DS-1501 | Phase 1 Clinical | Daiichi Sankyo Co Ltd | Osteoporosis | 상세 |
| BSI-060T | PYX-106; BSI-060T | Phase 1 Clinical | Biosion Inc | Neoplasm Metastasis; Solid tumours | 상세 |
제품 리뷰
1***22019-10-11
6사람들이 좋아합니다Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.- 1***32019-10-11 1사람들이 좋아합니다The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
- 1***22019-10-12 8사람들이 좋아합니다We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.
- 분자 정보
- 제품 목록
- 제품 리뷰
- 임상 약물 정보