언어 선택

Serpin A1

Serpin A1 분자 정보

영어 이름	Alpha-1-antiproteinase	시판 약물 수	2
임상 약물 수	14	표적 별명	Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1
최고 연구 개발 단계	Approved

영어 이름	Alpha-1-antiproteinase
표적 별명	Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1
시판 약물 수	2
임상 약물 수	14
최고 연구 개발 단계	Approved

Serpin A1 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
SE1-H5226	Human	HEK293	Human Serpin A1 Protein, His Tag

총 수량1

Serpin A1분자 배경

Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).

Serpin A1분자 별명

SerpinA1,PI,A1A,AAT,PI1,A1AT,MGC9222,PRO2275,MGC23330,alpha1AT,SPAAT

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Fazirsiran	TAK-999; ADS-001; ARO-AAT	Phase 3 Clinical	Arrowhead Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd	alpha 1-Antitrypsin Deficiency; Hepatic Insufficiency	상세
YOLT-202	YOLT-202	Phase 3 Clinical	Shanghai Yaotang Biotechnology Co Ltd	alpha 1-Antitrypsin Deficiency; Genetic Diseases, Inborn	상세
Efdoralprin alfa	INBRX-101; AT-292; rhAAT-Fc; AAT-IgG-Fc; AAT-Fc; SAR447537; SAR-447537	Phase 2 Clinical	Arecor Ltd, Inhibrx	alpha 1-Antitrypsin Deficiency; Emphysema	상세
TSRA-196	TSRA-196	Phase 2 Clinical	Tessera Therapeutics Inc	alpha 1-Antitrypsin Deficiency	상세
VX-864	VX-864	Phase 2 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	상세
KRRO-110	KRRO-110	Phase 2 Clinical	Korro Bio Inc	alpha 1-Antitrypsin Deficiency	상세
WVE-006	WVE-006; GSK-5462688	Phase 2 Clinical	Wave Life Sciences Ltd	alpha 1-Antitrypsin Deficiency	상세
BEAM-302	α1-AD; α-1-AD; BEAM-302	Phase 2 Clinical	Beam Therapeutics Inc	alpha 1-Antitrypsin Deficiency	상세
adeno-associated virus gene therapy (University of Massachusetts/University of Florida/NHLBI)		Phase 1 Clinical	University of Massachusetts	alpha 1-Antitrypsin Deficiency	상세
KB-408	KB-408	Phase 1 Clinical	Krystal Biotech Inc	alpha 1-Antitrypsin Deficiency	상세
VX-668	VX-668; VX668	Phase 1 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	상세
VX-634	VX-634	Phase 1 Clinical	Vertex Pharmaceuticals Incorporated	alpha 1-Antitrypsin Deficiency	상세
BMN-349	BMN-349	Phase 1 Clinical	Biomarin Pharmaceutical Inc	alpha 1-Antitrypsin Deficiency	상세
Alpha-1 antitrypsin (Kalytera Therapeutics)		Clinical	Clalit Health Services		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Alpha1-proteinase inhibitor (Human, Grifols)	TAL-6004	Approved	Bayer AG, Grifols Sa	Prolastin, Prolastin-c	United States	alpha 1-Antitrypsin Deficiency	null	1987-12-02	alpha 1-Antitrypsin Deficiency; Coronavirus Disease 2019 (COVID-19); Cystic Fibrosis; Pancreatitis, Chronic; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema	상세
Alfalastin (LFB SA)		Approved	Lfb Biotechnologies Sas	Alfalastin	France	alpha 1-Antitrypsin Deficiency	Lfb Biotechnologies Sas	2005-08-01	alpha 1-Antitrypsin Deficiency	상세