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PVRIG

PVRIG Overview

English Name	Transmembrane protein PVRIG	Approved Drugs	0
Drugs in Clinical Trials	7	Target Synonym	PVRIG，PVR Related Immunoglobulin Domain Containing，CD112 Receptor，Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein，Poliovirus Receptor Related Immunoglobulin Domain Containing，Nectin-2 Receptor，C7orf15，CD112R，Transmembrane Protein PVRIG，MGC2463
Highest Development Stage	Phase 2 Clinical

English Name	Transmembrane protein PVRIG
Target Synonym	PVRIG，PVR Related Immunoglobulin Domain Containing，CD112 Receptor，Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein，Poliovirus Receptor Related Immunoglobulin Domain Containing，Nectin-2 Receptor，C7orf15，CD112R，Transmembrane Protein PVRIG，MGC2463
Approved Drugs	0
Drugs in Clinical Trials	7
Highest Development Stage	Phase 2 Clinical

PVRIG Product List

Product Category
Protein (11)
Product Status
Launched (11)
Species
Human (5)Mouse (4)Cynomolgus (2)
Tag
His Tag (4)Fc Tag (3)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)Fc Tag & Avi Tag (1)
Conjugate
Unconjugated (8)Biotin-labeled (3)

Cat. No.	Species	Host	Product Description
HOT PVG-H5257	Human	HEK293	Human PVRIG Protein, Fc Tag, low endotoxin (MALS verified)
HOT PVG-H5259	Human	HEK293	Human PVRIG Protein, Mouse IgG2a Fc Tag (MALS verified)
HOT PVG-H52H4	Human	HEK293	Human PVRIG Protein, His Tag
HOT PVG-H82E3	Human	HEK293	Biotinylated Human PVRIG Protein, His,Avitag™
PVG-H52H5	Human	HEK293	Human PVRIG Protein, His Tag (MALS verified)
PVG-M5257	Mouse	HEK293	Mouse PVRIG Protein, Fc Tag (MALS verified)
PVG-M52H7	Mouse	HEK293	Mouse PVRIG Protein, His Tag (MALS verified)
PVG-M82E3	Mouse	HEK293	Biotinylated Mouse PVRIG Protein, His,Avitag™
PVG-M82F3	Mouse	HEK293	Biotinylated Mouse PVRIG Protein, Fc,Avitag™ (MALS verified)
PVG-C5259	Cynomolgus	HEK293	Cynomolgus PVRIG Protein, Fc Tag (MALS verified)

Total: 11

PVRIG Background

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

PVRIG Synonyms

C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor

Antibody Project Trading Platform

Project Name	Project Stage	Molecule Type	Molecule Source	Disease Area	Indication
TIGIT&PVRIG BsAb - 01	PCC	Monoclonal	Humanized Mouse	Solid Tumor	Solid tumor

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
COM-701	COM-701	Phase 2 Clinical	Compugen Ltd	Breast Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Head and Neck Neoplasms; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
PM-1009	PM1009	Phase 2 Clinical		Carcinoma, Hepatocellular; Liver Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours	Details
SIM-0348	SIM-0348	Phase 1 Clinical	Simcere Pharmaceutical Group Ltd	Neoplasms; Solid tumours	Details
GSK-4381562	SRF-813; GSK-4381562; GSK-4381562A; GSK4381562A; GSK’562	Phase 1 Clinical	Surface Oncology Inc	Neoplasms; Solid tumours	Details
NM1F	NM1F; TGI-2	Phase 1 Clinical	Hefei TG ImmunoPharma Co Ltd	Colorectal Neoplasms; Melanoma; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
SHR-2002	SHR-2002	Phase 1 Clinical	Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd	Neoplasms	Details
JS-009	JS009; TAB009; JS-009	Phase 1 Clinical	Shanghai Junshi Biosciences Co Ltd	Neoplasms; Solid tumours	Details