Prolactin R
Prolactin R 분자 정보
| 영어 이름 | Prolactin receptor | 시판 약물 수 | 0 |
| 임상 약물 수 | 2 | 표적 별명 | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| 최고 연구 개발 단계 | Phase 3 Clinical | ||
| 영어 이름 | Prolactin receptor |
| 표적 별명 | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| 시판 약물 수 | 0 |
| 임상 약물 수 | 2 |
| 최고 연구 개발 단계 | Phase 3 Clinical |
Prolactin R 제품 목록
- 속성
Protein (7)
- 제품 라이브러리
온라인 (7)
- 종
Human (4)Cynomolgus (1)Rat (1)Mouse (1)
- 태그
Fc Tag (1)His Tag (5)His Tag & Avi Tag (1)
- 마커
Unconjugated (6)Biotin-labeled (1)
| 제품 번호 | 종 | 발현 시스템 | 제품 설명 | 단백질 구조 | 순도 | 특성 |
|---|---|---|---|---|---|---|
 Human | HEK293 | Human Prolactin R / PRLR Protein, Fc Tag |  |  |  | |
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag&Tag Free, low endotoxin (MALS verified) | | | ||
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag |  | | | |
| Human | HEK293 | Biotinylated Human Prolactin R / PRLR Protein, His,Avitag™ (MALS verified) |  | | | |
 Mouse | HEK293 | Mouse Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | |  | |
 Cynomolgus | HEK293 | Cynomolgus Prolactin R Protein, His Tag (MALS verified) |  | | | |
 Rat | HEK293 | Rat Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | | |
총 수량7
- 1
Prolactin R분자 배경
The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily, widely expressed in mammary gland, reproductive organs, liver, and brain. Signal activation is initiated when a single prolactin (PRL) molecule binds to this pre-dimerized PRLR, inducing a specific conformational change. This triggers the associated JAK2 kinases to phosphorylate each other and the receptor, ultimately leading to the recruitment and activation of downstream STAT5 transcription factors. This precise mechanism governs essential physiological processes, including lactation, reproduction, metabolism, and immune function, and its dysregulation is implicated in diseases such as certain cancers and endometriosis.
Prolactin R분자 별명
Prolactin R,PRLR,PRL-R
임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| BAY-1158061 | BAY-1158061; HMI-115 | Phase 3 Clinical | Bayer AG | Alopecia; Endometriosis; Pain | 상세 |
| ABS-201 | ABS-201 | Phase 2 Clinical | Absci Corp | Alopecia; Skin Diseases | 상세 |
- 분자 정보
- 제품 목록
- 임상 약물 정보