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Pleiotrophin

Pleiotrophin Overview

English Name	Pleiotrophin	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	HBNF，HBGF8，NEGF1，Heparin-Binding Neurite Outgrowth-Promoting Factor 1，Heparin-Binding Growth-Associated Molecule，Heparin-Binding Growth Factor 8，Heparin-Binding Brain Mitogen，Osteoblast-Specific Factor 1，HB-GAM，HBGF-8，HBNF-1，OSF-1，HBBM，Pleiotrophin (Heparin Binding Growth Factor 8， Neurite Growth-Promoting Factor 1)，Heparin-Binding Neurite Outgrowth Promoting Factor，Heparin-Binding Neurite Outgrowth-Promoting Factor，Neurite Growth-Promoting Factor 1，Heparin Affin Regulatory Protein，Heparin Binding Growth Factor 8，HBNF1，HARP
Highest Development Stage	Preclinical

English Name	Pleiotrophin
Target Synonym	HBNF，HBGF8，NEGF1，Heparin-Binding Neurite Outgrowth-Promoting Factor 1，Heparin-Binding Growth-Associated Molecule，Heparin-Binding Growth Factor 8，Heparin-Binding Brain Mitogen，Osteoblast-Specific Factor 1，HB-GAM，HBGF-8，HBNF-1，OSF-1，HBBM，Pleiotrophin (Heparin Binding Growth Factor 8， Neurite Growth-Promoting Factor 1)，Heparin-Binding Neurite Outgrowth Promoting Factor，Heparin-Binding Neurite Outgrowth-Promoting Factor，Neurite Growth-Promoting Factor 1，Heparin Affin Regulatory Protein，Heparin Binding Growth Factor 8，HBNF1，HARP
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

Pleiotrophin Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
PLN-H5244	Human	E. coli	Human Pleiotrophin / PTN Protein, His Tag, premium grade

Total: 1

Pleiotrophin Background

Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.

Pleiotrophin Synonyms

neurite growth-promoting factor 1,HARP,HBBM,HB-GAM,HBGF8,HBNF,HBNF1,HBNF-1,Heparin-binding brain mitogen,HNGF-8,NEGF1HBGF-8,OSF-1,Osteoblast-specific factor 1