Pleiotrophin

English

Pleiotrophin 분자 정보

Molecule Name

Pleiotrophin

분자 별명

neurite growth-promoting factor 1,HARP,HBBM,HB-GAM,HBGF8,HBNF,HBNF1,HBNF-1,Heparin-binding brain mitogen,HNGF-8,NEGF1HBGF-8,OSF-1,Osteoblast-specific factor 1

Drug Development Progress

임상 약물 수0

시판 약물 수0

최고 연구 개발 단계Preclinical

표적 별명

HBNF，HBGF8，NEGF1，Heparin-Binding Neurite Outgrowth-Promoting Factor 1，Heparin-Binding Growth-Associated Molecule，Heparin-Binding Growth Factor 8，Heparin-Binding Brain Mitogen，Osteoblast-Specific Factor 1，HB-GAM，HBGF-8，HBNF-1，OSF-1，HBBM，Pleiotrophin (Heparin Binding Growth Factor 8， Neurite Growth-Promoting Factor 1)，Heparin-Binding Neurite Outgrowth Promoting Factor，Heparin-Binding Neurite Outgrowth-Promoting Factor，Neurite Growth-Promoting Factor 1，Heparin Affin Regulatory Protein，Heparin Binding Growth Factor 8，HBNF1，HARP

분자 배경

Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.