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PD-L1

PD-L1

PD-L1 분자 정보

Molecule Name
Programmed death-ligand 1
분자 별명
PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1
Drug Development Progress
임상 약물 수172
시판 약물 수12
최고 연구 개발 단계Approved
표적 별명
HPD-L1，Programmed Cell Death 1 Ligand 1，PDCD1L1，B7H1，PDL1，Programmed Death Ligand 1，B7-H1，B7-H，B7-H1 Antigen，CD274，B7 homolog 1，PDCD1 ligand 1，PD-L1，PDCD1LG1，CD274 Molecule，CD274 Antigen
분자 배경
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

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