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PCSK9

PCSK9 분자 정보

영어 이름	Proprotein convertase subtilisin kexin type 9	시판 약물 수	8
임상 약물 수	36	표적 별명	EC 3.4.21，Neural apoptosis-regulated convertase 1，Proprotein convertase 9，NARC1，PSEC0052，PCSK9，NARC-1，EC:3.4.21.-，Proprotein Convertase Subtilisin/Kexin Type 9，Subtilisin/Kexin-Like Protease PC9，PC9，Convertase Subtilisin/Kexin Type 9 Preproprotein，Hypercholesterolemia， Autosomal Dominant 3，EC 3.4.21.-，HCHOLA3，LDLCQ1，FH3，EC 3.4.21.111，Neural Apoptosis Regulated Convertase 1，FHCL3
최고 연구 개발 단계	Approved

영어 이름	Proprotein convertase subtilisin kexin type 9
표적 별명	EC 3.4.21，Neural apoptosis-regulated convertase 1，Proprotein convertase 9，NARC1，PSEC0052，PCSK9，NARC-1，EC:3.4.21.-，Proprotein Convertase Subtilisin/Kexin Type 9，Subtilisin/Kexin-Like Protease PC9，PC9，Convertase Subtilisin/Kexin Type 9 Preproprotein，Hypercholesterolemia， Autosomal Dominant 3，EC 3.4.21.-，HCHOLA3，LDLCQ1，FH3，EC 3.4.21.111，Neural Apoptosis Regulated Convertase 1，FHCL3
시판 약물 수	8
임상 약물 수	36
최고 연구 개발 단계	Approved

PCSK9 제품 목록

속성
Protein (13)Kits (3)
제품 라이브러리
온라인 (16)
종
Human (9)Mouse (2)Rat (1)Rhesus macaque (1)Cynomolgus (2)Hamster (1)
태그
His Tag (8)His Tag & Avi Tag (4)Fc Tag (1)- (3)
마커
Unconjugated (9)Biotin-labeled (4)- (3)

제품 번호	종	발현 시스템	제품 설명
HOT AIDD‑Ready PC9-H5223	Human	HEK293	Human PCSK9 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
HOT AIDD‑Ready PC9-H5256	Human	HEK293	Human PCSK9 Protein, Fc Tag
HOT PC9-H82E7	Human	HEK293	Biotinylated Human PCSK9 Protein, Avitag™,His Tag (MALS verified)
HOT AIDD‑Ready PCY-H5225	Human	HEK293	Human PCSK9 (D374Y) Protein, His Tag, low endotoxin (MALS verified)
HOT PCY-H82E7	Human	HEK293	Biotinylated Human PCSK9 (D374Y) Protein, Avitag™,His Tag
HOT AIDD‑Ready PC9-C5223	Cynomolgus	HEK293	Cynomolgus PCSK9 Protein, His Tag, low endotoxin
CEA-C202	Human	-	Human PCSK9 ELISA Kit
EP-103	Human	-	PCSK9 [Biotinylated] : LDL R Inhibitor Screening ELISA Assay Pair
AIDD‑Ready FRT-P040	Human	-	Human PCSK9 / LDL R Inhibitor Screening Kit (TR-FRET)
PC9-H52H7	Human	HEK293	Human PCSK9 Protein, C-terminal domain truncated, His Tag, low endotoxin

총 수량16

제품 문의

PCSK9분자 배경

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

PCSK9분자 별명

PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Recombinant human anti-PCSK9 monoclonal antibody (Salubris)	SAL003	Phase 3 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Dyslipidemias; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias	상세
SYH-2053	SYH2053; SYH-2053	Phase 3 Clinical	CSPC Pharmaceutical Group Ltd	Dyslipidemias; Heterozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias; Sitosterolemia	상세
RBD-7022	RBD7022; RBD-7022; SR043; SR-043; QLC-7401	Phase 3 Clinical	Suzhou Ribo Life Science Co Ltd	Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias; Sitosterolemia	상세
Laroprovstat	AZD-0780; AZD0780	Phase 3 Clinical	Dogma Therapeutics	Atherosclerosis; Cardiovascular Diseases; Dyslipidemias; Hepatic Insufficiency; Heterozygous familial hypercholesterolemia; Renal Insufficiency	상세
Enlicitide Decanoate	MK-0616	Phase 3 Clinical	Merck Sharp & Dohme Corp	Arteriosclerosis; Atherosclerosis; Cardiovascular Diseases; Hepatic Insufficiency; Heterozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Kidney Diseases; Renal Insufficiency; Sitosterolemia	상세
AZD-8233	AZD-8233; IONIS-AZ4-2.5-LRx; ION-449	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Kidney Failure, Chronic	상세
CVI-LM-001	CVI-LM-001; CVI-LM001; C-8304	Phase 2 Clinical	Xiwei'Ai Medicine Technology (Shanghai) Co Ltd	Hypercholesterolemia; Hyperlipidemias	상세
ATX-304	O-304; ATX-304; O-304X	Phase 2 Clinical	Betagenon Ab	Diabetes Mellitus, Type 2; Mitochondrial Diseases; Peripheral Arterial Disease	상세
MIL-86	MIL-86	Phase 2 Clinical	Beijing Mabworks Biotech Co Ltd	Cardiovascular Diseases; Heterozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II	상세
NNC0385-0434	NNC0385-0434; NN-6435; NNC 0385 0434	Phase 2 Clinical	Novo Nordisk A/S	Arteriosclerosis; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Hypercholesterolemia; Renal Insufficiency, Chronic	상세
ARO-DIMER-PA	ARO-DIMER-PA	Phase 2 Clinical	Arrowhead Pharmaceuticals Inc	Hyperlipidemia, Familial Combined; Hyperlipidemias	상세
BEBT-701	BEBT-701	Phase 2 Clinical	Guangzhou BeBetter Medicine Technology Co	Hypercholesterolemia; Hyperlipidemias; Hypertension	상세
DNV-001	DNV-001; DNV001	Phase 2 Clinical	Hangzhou Dingle New Biotechnology Co Ltd	Dyslipidemias; Hypercholesterolemia; Hyperlipidemia, Familial Combined	상세
YKYY-015	YKYY015; YKYY-015	Phase 2 Clinical	Hangzhou Tianlong Pharmaceutical Co Ltd	Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias	상세
PCSK9 Inhibitors therapy(Guangdong Provincial People'S Hospital)		Phase 2 Clinical	Guangdong Provincial People'S Hospital	Colorectal Neoplasms	상세
Recombinant human anti-PCSK9 monoclonal antibody (Tasly Pharm)	B1655; B-1655	Phase 1 Clinical	Tianjin Tasly Pharmaceutical Co Ltd	Hypercholesterolemia	상세
DC-371739	JYP-0739; DC-371739	Phase 1 Clinical	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Dyslipidemias; Hypercholesterolemia; Hyperlipidemias	상세
Anti-PCSK9 monoclonal antibody (Biocad)		Phase 1 Clinical	BIOCAD JSC	Cardiovascular Diseases	상세
ATH-04	ATH-04; Affitope AT04A	Phase 1 Clinical	Affiris Ag	Atherosclerosis	상세
VERVE-101	VERVE-101	Phase 1 Clinical	Broad Institute, Harvard University	Atherosclerosis; Cardiovascular Diseases; Heterozygous familial hypercholesterolemia; Hypercholesterolemia	상세
ART-002g1	ART002g1; ART-002g1	Phase 1 Clinical	Shanghai Jiao Tong University Affiliated First People'S Hospital	Heterozygous familial hypercholesterolemia	상세
RN-5681	RN-5681; RN5681	Phase 1 Clinical	Rona Therapeutics Inc	Atherosclerosis; Hypercholesterolemia	상세
PRD-001	PRD001; PRD-001	Phase 1 Clinical	PRD Therapeutics Inc	Fatty Liver; Homozygous familial hypercholesterolemia; Metabolic Dysfunction-Associated Steatotic Liver Disease	상세
ZRC-3306	ZRC-3306	Phase 1 Clinical	Zydus Lifesciences Ltd	Dyslipidemias	상세
STX-1150	STX1150; STX-1150	Phase 1 Clinical	Scribe Therapeutics Inc	Cardiovascular Diseases; Hypercholesterolemia	상세
SAL-092	SAL092; SAL-092	Phase 1 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Dyslipidemias; Hypercholesterolemia	상세
VERVE-102	VERVE-102	Phase 1 Clinical	Verve Therapeutics Inc	Atherosclerosis; Coronary Disease; Heterozygous familial hypercholesterolemia	상세
SRSD-101	SRSD101; SRSD-101; SRS001; SRS-001	Phase 1 Clinical	Sirius Therapeutics Inc	Cardiovascular Diseases; Hypercholesterolemia	상세
SGB-3403	SGB-3403	Phase 1 Clinical	Suzhou Sanegene Bio Inc	Atherosclerosis; Heterozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias	상세
RN-0191	RN0191	Phase 1 Clinical	Darui Biomedical Technology (Shanghai) Co Ltd	Atherosclerosis; Dyslipidemias; Hypercholesterolemia	상세
RP-910	RP910; RP-910	Phase 1 Clinical	Risen(Shanghai) Pharma Tech Co Ltd	Hyperlipidemias; Metabolic Diseases	상세
SAL-061	YOLT-101; SAL-061; SAL061	Phase 1 Clinical	Shanghai Yaotang Biotechnology Co Ltd	Heterozygous familial hypercholesterolemia; Hyperlipoproteinemia Type II	상세
JX-7002	JX7002; JX-7002	Phase 1 Clinical	Zhejiang Jingxin Pharmaceutical Co Ltd	Hypercholesterolemia; Hyperlipidemias	상세
NN-6434	NN-6434	Phase 1 Clinical	Novo Nordisk A/S		상세
PCSK9 modulator (Genekey Biotech)		Phase 1 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Inflammation; Metabolic Diseases	상세
ART-002(Ruizheng Gene)	ART002; ART-002; ART-002(Ruizheng Gene)	Clinical	Ruizheng Gene (Suzhou) Co Ltd	Heterozygous familial hypercholesterolemia	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Inclisiran sodium	ALN-60212; PCSK9si; ALN-PCSsc; KJX839; KJX-839	Approved	Alnylam Pharmaceuticals Inc	Leqvio, 乐可为	EU	Dyslipidemias; Hypercholesterolemia	Novartis Europharm Ltd	2020-12-09	Acute Coronary Syndrome; Atherosclerosis; Cardiovascular Diseases; Carotid Artery Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Heterozygous familial hypercholesterolemia; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Hypolipoproteinemias; Myocardial Infarction; Renal Insufficiency; Stroke	상세
Ongericimab	JS-002	Approved	Shanghai Junshi Biosciences Co Ltd	君适达	Mainland China	Hypercholesterolemia; Dyslipidemias	Shanghai Junshi Biosciences Co Ltd	2024-10-09	Atherosclerosis; Dyslipidemias; Heterozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hypertriglyceridemia; Neoplasms	상세
Lerodalcibep	LIB-003; HST 101	Approved	Lib Therapeutics Llc		United States	Hypercholesterolemia	LIB Therapeutics Inc	2025-12-12	Arteriosclerosis; Atherosclerosis; Cardiovascular Diseases; Dyslipidemias; Heterozygous familial hypercholesterolemia; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Metabolic Diseases; Stroke	상세
Ebronucimab	AK-102	Approved	Yabao Us Pharmaceutical Co Ltd	伊喜宁	Mainland China	Hypercholesterolemia; Dyslipidemias	Kang Rong Dongfang (Guangdong) Pharmaceutical Co Ltd	2024-09-26	Dyslipidemias; Heterozygous familial hypercholesterolemia; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type II	상세
Recaticimab	SHR-1209	Approved	Jiangsu Hengrui Medicine Co Ltd	艾心安	Mainland China	Hypercholesterolemia; Dyslipidemias	Guangdong Hengrui Pharmaceutical Co Ltd	2025-01-08	Dyslipidemias; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type II; Intracranial Arteriosclerosis	상세
Evolocumab	AMG-145	Approved	Amgen Inc, Astellas Pharma Inc	瑞百安, Repatha	EU	Dyslipidemias; Hypercholesterolemia	Amgen Europe Bv	2015-07-17	Acute Coronary Syndrome; Aortic Aneurysm, Abdominal; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Glioblastoma; Glioma; Heart Failure, Systolic; Heterozygous familial hypercholesterolemia; HIV Infections; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Rejection in heart transplantation; Sepsis; ST Elevation Myocardial Infarction; Stroke	상세
Tafolecimab	IBI-306	Approved		信必乐	Mainland China	Dyslipidemias; Hypercholesterolemia	Innovent Biologics(Suzhou) Co Ltd	2023-08-15	Aortic Valve Stenosis; Dyslipidemias; Heterozygous familial hypercholesterolemia; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias	상세
Alirocumab	316P; REGN-727; SAR-236553	Approved	Regeneron Pharmaceuticals Inc, Sanofi	波立达, Praluent	United States	Hypercholesterolemia	Regeneron Pharmaceuticals Inc	2015-07-24	Acute Coronary Syndrome; Angina Pectoris; Atherosclerosis; Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus, Type 2; Drinking Behavior; Dyslipidemias; Hemorrhage; Heterozygous familial hypercholesterolemia; HIV Infections; Homozygous familial hypercholesterolemia; Hypercholesterolemia; Hyperlipidemias; Intracranial Arteriosclerosis; Ischemic Stroke; Liver Diseases, Alcoholic; Myocardial Infarction; Plaque, Atherosclerotic; Sepsis; Shock, Septic; ST Elevation Myocardial Infarction; Stroke; Vascular Diseases	상세

제품 리뷰

1***02019-10-11
0사람들이 좋아합니다
Biotinylated Human PCSK9 (D374Y) Protein, Avitag™,His Tag
Experiment purpose: antibody screening. Experiment method: Elisa. User experience: I purchased both small and big packages. It is stable from batch to batch and has excellent bioactivity. The experiment results are also very satisfying.

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