Nucleolin 분자 정보
Molecule Name
Nucleolin
분자 별명
Nucleolin,NCL,Protein C23
Drug Development Progress
임상 약물 수4
시판 약물 수1
최고 연구 개발 단계Approved
표적 별명
NCL，Nucleolin，Protein C23，Nsr1，C23
분자 배경
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Nucleolin 제품 목록
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임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| IPP-204106 | N6L; Nucant-6L; IPP-204106; IPP-204106N; poyplexed IPP-204106 | Phase 2 Clinical | Immupharma Plc | Neoplasms; Solid tumours | 상세 |
| AS-1411 | AGRO-100; GR-026-B; AS-1411; ACT-GRO-777 | Phase 2 Clinical | Antisoma, University Of Alabama At Birmingham, University Of Louisville | Neoplasms; Solid tumours | 상세 |
| Pegylated recombinant human endostatin (Tsinghua University) | M-2ES; CRB-0401 | Phase 1 Clinical | Beijing Proji Pharmaceutical Technology Co Ltd, Beijing Protgen Biotechnology Development Co Ltd, Tsinghua University | Carcinoma, Non-Small-Cell Lung; Neoplasms; Pancreatic Neoplasms; Solid tumours | 상세 |
| APTA-16 | APTA-16; SJP1604 | Phase 1 Clinical | Aptabio Therapeutics Inc | Leukemia, Myeloid, Acute; Liver Neoplasms; Myelodysplastic Syndromes | 상세 |
시판 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 가장 빠른 브랜드 이름 | 가장 빠른 승인 국가 | 가장 빠른 적응증 | 가장 빠른 승인 회사 | 가장 빠른 승인 날짜 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|---|---|---|---|---|
| Recombinant human endostatin (Simcere) | YH-16 | Approved | Jiangsu Simcere Pharmaceutical Co Ltd | Endostar, 恩度, Endu | Mainland China | Carcinoma, Non-Small-Cell Lung | Shandong Xiansheng Zaiming Biopharmaceutical Co Ltd | 2005-09-12 | Ascites; Brain metastases; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Head and Neck Neoplasms; Nasopharyngeal Carcinoma; Osteosarcoma; Pleural Effusion, Malignant | 상세 |