NOTCH2

NOTCH2 분자 정보

영어 이름Neurogenic locus notch homolog protein 2시판 약물 수0
임상 약물 수0표적 별명N2ECD,NOTCH2,N2ICD,Notch 2,hN2,Neurogenic Locus Notch Homolog Protein 2,Notch (Drosophila) Homolog 2,Notch Homolog 2 (Drosophila),Notch Homolog 2,HJCYS,AGS2,Receptor, Notch2,Notch Receptor 2
최고 연구 개발 단계Preclinical
영어 이름Neurogenic locus notch homolog protein 2
표적 별명N2ECD,NOTCH2,N2ICD,Notch 2,hN2,Neurogenic Locus Notch Homolog Protein 2,Notch (Drosophila) Homolog 2,Notch Homolog 2 (Drosophila),Notch Homolog 2,HJCYS,AGS2,Receptor, Notch2,Notch Receptor 2
시판 약물 수0
임상 약물 수0
최고 연구 개발 단계Preclinical

NOTCH2 제품 목록

  • 속성

    Protein (1)

  • 제품 라이브러리

    온라인 (1)

  • Human (1)

  • 태그

    Fc Tag (1)

  • 마커

    Unconjugated (1)

제품 번호발현 시스템제품 설명단백질 구조순도특성
NO2-H5255
Human
HEK293
Human NOTCH2 Protein, Fc Tag (MALS verified)
총 수량1
  • 1

NOTCH2분자 배경

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

NOTCH2분자 별명

NOTCH2,hN2,N2ECD
  • 분자 정보
  • 제품 목록
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