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NKp46

NKp46 Overview

English Name	Natural cytotoxicity triggering receptor 1	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	NK cell-activating receptor，NK-p46，Lymphocyte antigen 94 homolog，NKp46，hNKp46，Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46)，Natural killer cell p46-related protein，LY94，Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)，CD335 Antigen，CD335
Highest Development Stage	Phase 2 Clinical

English Name	Natural cytotoxicity triggering receptor 1
Target Synonym	NK cell-activating receptor，NK-p46，Lymphocyte antigen 94 homolog，NKp46，hNKp46，Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46)，Natural killer cell p46-related protein，LY94，Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)，CD335 Antigen，CD335
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

NKp46 Product List

Product Category
Protein (16)Cell (2)Antibody (1)
Product Status
Launched (19)
Species
Human (12)Cynomolgus (3)Mouse (4)
Tag
Fc Tag (4)His Tag (6)Llama IgG Fc Tag (2)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)- (2)Tag Free (1)
Conjugate
Unconjugated (10)Biotin-labeled (5)- (2)PE Labeled (1)FITC Labeled (1)

Cat. No.	Species	Host	Product Description
HOT NC1-H52H4	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, His Tag, low endotoxin (MALS verified)
HOT NC1-H52H6	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, His Tag
HOT NK6-H82E2	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, His Tag, ultra sensitivity (primary amine labeling)
HOT NP6-H82H3	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, His,Avitag™, premium grade
CHEK-ATP153	Human	HEK293	HEK293/Human NKp46 Stable Cell Line
NC1-H5255	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin
NC1-H5257	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag, premium grade
NC1-H5258	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H5259	Human	HEK293	Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H82F9	Human	HEK293	Biotinylated Human NKp46 / NCR1 / CD335 Protein, Fc,Avitag™, premium grade

Total: 19

NKp46 Background

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

NKp46 Synonyms

NCR1,LY94,CD335,NK-p46,hNKp46

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NY-303	NY-303	Phase 2 Clinical	NAYA Biosciences Inc	Carcinoma, Hepatocellular; Solid tumours	Details
IPH-6501	IPH-6501; IPH-65	Phase 2 Clinical	Innate Pharma SA	Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms	Details
SAR-443579	SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101	Phase 1 Clinical	Sanofi	Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Details