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NGFR

NGFR Overview

English Name	Low affinity neurotrophin receptor p75NTR	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	Gp80-LNGFR，P75NTR，CD271 Antigen，Low-Affinity Nerve Growth Factor Receptor，Tumor Necrosis Factor Receptor Superfamily Member 16，Low Affinity Nerve Growth Factor Receptor，Low Affinity Neurotrophin Receptor P75NTR，Nerve Growth Factor Receptor (TNFR Superfamily， Member 16)，TNFR Superfamily， Member 16，Nerve Growth Factor Receptor，P75 ICD，P75(NTR)，TNFRSF16，CD271
Highest Development Stage	Phase 2 Clinical

English Name	Low affinity neurotrophin receptor p75NTR
Target Synonym	Gp80-LNGFR，P75NTR，CD271 Antigen，Low-Affinity Nerve Growth Factor Receptor，Tumor Necrosis Factor Receptor Superfamily Member 16，Low Affinity Nerve Growth Factor Receptor，Low Affinity Neurotrophin Receptor P75NTR，Nerve Growth Factor Receptor (TNFR Superfamily， Member 16)，TNFR Superfamily， Member 16，Nerve Growth Factor Receptor，P75 ICD，P75(NTR)，TNFRSF16，CD271
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

NGFR Product List

Product Category
Protein (1)Cell (1)
Product Status
Launched (2)
Species
Human (2)
Tag
Fc Tag (1)- (1)
Conjugate
Unconjugated (1)- (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
CHEK-ATP157	Human	HEK293	HEK293/Human NGFR Stable Cell Line
NGR-H5254	Human	HEK293	Human NGFR / TNFRSF16 Protein, Fc Tag (MALS & BLI verified)

Total: 2

NGFR Background

The p75 neurotrophin receptor (p75NTR) was originally identified as a low-affinity receptor for neurotrophins(NGF R).p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.

NGFR Synonyms

tumor necrosis factor receptor superfamily member 16; CD271; Gp80-LNGFR; member 16 nerve growth factor receptor; p75 ICD; p75 NTR

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
LM11A-31	LM11A-31; LM11A-31-BHS	Phase 2 Clinical	Pharmatrophix Inc	Alzheimer Disease; Supranuclear Palsy, Progressive	Details
Recombinant human nerve growth factor (Xintrum Pharmacouticals)	rh-NGF; ZX1305; ZX-1305; ZX1305E; ZX-1305-E	Phase 2 Clinical	Jiangsu Zhongxin Pharmaceutical Co Ltd	Glaucoma, Open-Angle; Keratitis; Optic Nerve Injuries	Details
Recombinant Human Nerve Growth Factor (Kerun Biopharmaceutical)		Phase 1 Clinical	Chongqing Kerun Biologic Pharmaceutical Development Co Ltd	Keratitis; Xerophthalmia	Details