언어 선택

Neprilysin

Neprilysin 분자 정보

영어 이름	Neprilysin	시판 약물 수	3
임상 약물 수	8	표적 별명	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
최고 연구 개발 단계	Approved

영어 이름	Neprilysin
표적 별명	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
시판 약물 수	3
임상 약물 수	8
최고 연구 개발 단계	Approved

Neprilysin 제품 목록

속성
Protein (3)
제품 라이브러리
온라인 (3)
종
Human (3)
태그
Fc Tag (1)Tag Free (1)His Tag (1)
마커
Unconjugated (3)

제품 번호	종	발현 시스템	제품 설명
MME-H521b	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Tag Free (active enzyme)
MME-H5243	Human	HEK293	Human Neprilysin / MME / CD10 Protein, His Tag (active enzyme, MALS verified)
MME-H526a	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Fc Tag

총 수량3

Neprilysin분자 배경

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Neprilysin분자 별명

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Dexecadotril		Phase 3 Clinical	Bioprojet Pharma	Gastrointestinal Diseases	상세
Sacubitril/Valsartan (Chong Kun Dang Pharmaceutical)	CKD-202A	Phase 3 Clinical	Chong Kun Dang Pharmaceutical Corp	Essential Hypertension	상세
QR-12000	QR-12000	Phase 3 Clinical	Wuhan Createrna Science and Technology Co Ltd	Essential Hypertension; Hypertension	상세
Debio-0827	PL-37; Debio-0827	Phase 2 Clinical	Pharmaleads	Pain	상세
Sacubitril	AHU-377	Phase 2 Clinical	Novartis Pharma Ag	Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diabetes Mellitus; Essential Hypertension; Heart Failure; Hypertension; Insulin Resistance; Metabolic Diseases	상세
Anti-CD10 CAR T-cell therapy (Zhujiang Hospital/Nanfang Hospital)		Phase 1 Clinical	Southern Medical University Zhujing Hospital	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	상세
Sacubitril Valsartan Sodium Extended-Relesae Tablets(Taizhou Overseas Pharma)		Phase 1 Clinical	Taizhou Overseas Pharmaceuticals Co Ltd	Heart Failure	상세
Sacubitril/Allisartan Isoproxil/Amlodipine Besylate		Phase 1 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Essential Hypertension	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Sacubitril/Allisartan Isoproxil	AHU-377/EXP3174; S-086	Approved	Shenzhen Salubris Pharmaceuticals Co Ltd	信超妥	Mainland China	Essential Hypertension	Shenzhen Salubris Pharmaceuticals Co Ltd	2025-05-20	Essential Hypertension; Heart Failure; Hypertension	상세
Sacubitril/Valsartan Sodium Hydrate	LCZ-696; LCZ-696A	Approved	Novartis Pharma Ag	ENTRESTO SPRINKLE, Enresuto, Enrest, Entresto, Neparvis, 诺欣妥, 科畅欣	United States	Heart Failure	Novartis Pharmaceuticals Corp	2015-07-07	Breast Neoplasms; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronavirus Disease 2019 (COVID-19); Erectile Dysfunction; Essential Hypertension; Heart Defects, Congenital; Heart Diseases; Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Hepatic Insufficiency; Hypertension; Lymphoma; Myocardial Infarction; Obesity; Peripheral Arterial Disease; Postmyocardial Infarction Syndrome; Renal Insufficiency; Renal Insufficiency, Chronic; Ventricular Dysfunction, Left	상세
Racecadotril	Tiorfan; Hidrasec	Approved	Bioprojet Pharma		France	Diarrhea	Bioprojet Pharma	1993-03-23	Diarrhea; Diarrhea, Infantile; Sepsis	상세