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MAG / Siglec-4a

MAG / Siglec-4a 분자 정보

영어 이름	Myelin-associated glycoprotein	시판 약물 수	0
임상 약물 수	1	표적 별명	MAG，Siglec-4a，GMA，Sialic Acid Binding Ig-Like Lectin 4A，Myelin-Associated Glycoprotein，SIGLEC4A，S-MAG，SPG75，Myelin Associated Glycoprotein，Sialic Acid-Binding Immunoglobulin-Like Lectin 4A
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Myelin-associated glycoprotein
표적 별명	MAG，Siglec-4a，GMA，Sialic Acid Binding Ig-Like Lectin 4A，Myelin-Associated Glycoprotein，SIGLEC4A，S-MAG，SPG75，Myelin Associated Glycoprotein，Sialic Acid-Binding Immunoglobulin-Like Lectin 4A
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 2 Clinical

MAG / Siglec-4a 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Human (3)Mouse (1)
태그
His Tag (1)Fc Tag (1)His Tag & Avi Tag (2)
마커
Unconjugated (2)Biotin-labeled (2)

제품 번호	종	발현 시스템	제품 설명
HOT MAG-H5254	Human	HEK293	Human MAG / Siglec-4a Protein, Fc Tag
HOT MAG-H52H8	Human	HEK293	Human MAG / Siglec-4a Protein, His Tag
HOT MAG-H82E9	Human	HEK293	Biotinylated Human MAG / Siglec-4a Protein, His,Avitag™
MAG-M82E9	Mouse	HEK293	Biotinylated Mouse MAG / Siglec-4a Protein, His,Avitag™ (MALS verified)

총 수량4

MAG / Siglec-4a분자 배경

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.