언어 선택

MAdCAM-1

MAdCAM-1 분자 정보

영어 이름	Mucosal addressin cell adhesion molecule-1	시판 약물 수	1
임상 약물 수	4	표적 별명	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
최고 연구 개발 단계	Approved

영어 이름	Mucosal addressin cell adhesion molecule-1
표적 별명	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
시판 약물 수	1
임상 약물 수	4
최고 연구 개발 단계	Approved

MAdCAM-1 제품 목록

속성
Protein (7)Cell (1)
제품 라이브러리
온라인 (8)
종
Human (4)Cynomolgus (2)Mouse (2)
태그
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag (3)His Tag & Avi Tag (2)- (1)
마커
Unconjugated (4)Biotin-labeled (3)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT MAM-H5253	Human	HEK293	Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)
HOT MAM-H52H4	Human	HEK293	Human MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)
HOT MAM-H8251	Human	HEK293	Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)
CCHO-ATP241	Human	CHO	CHO/Human MAdCAM-1 Stable Cell Line
MAM-M52H3	Mouse	HEK293	Mouse MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)
MAM-M82E3	Mouse	HEK293	Biotinylated Mouse MAdCAM-1 Protein, His,Avitag™ (MALS verified)
MAM-C52H3	Cynomolgus	HEK293	Cynomolgus MAdCAM-1 Protein, His Tag, low endotoxin
MAM-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus MAdCAM-1 Protein, His,Avitag™ (MALS verified)

총 수량8

제품 문의

MAdCAM-1분자 배경

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

MAdCAM-1분자 별명

MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis	상세
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	상세
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	상세
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	상세