언어 선택

LILRB4

LILRB4 분자 정보

영어 이름	Leukocyte immunoglobulin-like receptor subfamily B member 4	시판 약물 수	0
임상 약물 수	7	표적 별명	CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Leukocyte immunoglobulin-like receptor subfamily B member 4
표적 별명	CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4
시판 약물 수	0
임상 약물 수	7
최고 연구 개발 단계	Phase 2 Clinical

LILRB4 제품 목록

속성
Protein (11)
제품 라이브러리
온라인 (11)
종
Cynomolgus (2)Mouse (2)Human (7)
태그
Fc Tag (3)His Tag (4)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)Fc Tag & Avi Tag (1)
마커
Unconjugated (6)FITC Labeled (2)Biotin-labeled (3)

제품 번호	종	발현 시스템	제품 설명
HOT LI4-H52H7	Human	HEK293	Human LILRB4 / CD85k / ILT3 Protein, His Tag, low endotoxin (MALS verified)
HOT LI4-H82E4	Human	HEK293	Biotinylated Human LILRB4 / CD85k / ILT3 Protein, His,Avitag™ (MALS verified)
HOT CDK-C5227	Cynomolgus	HEK293	Cynomolgus LILRB4 / CD85k / ILT3 Protein, His Tag (MALS verified)
LI4-H5256	Human	HEK293	Human LILRB4 / CD85k / ILT3 Protein, Fc Tag, low endotoxin (MALS verified)
LI4-H5257	Human	HEK293	Human LILRB4 / CD85k / ILT3 Protein, Mouse IgG2a Fc Tag (MALS verified)
LI4-H82F6	Human	HEK293	Biotinylated Human LILRB4 / CD85k / ILT3 Protein, Fc,Avitag™ (MALS verified)
LI4-HF254	Human	HEK293	FITC-Labeled Human LILRB4 / CD85k / ILT3 Protein, Fc Tag
LI4-HF2H3	Human	HEK293	FITC-Labeled Human LILRB4 / CD85k / ILT3 Protein, His Tag
CDK-M5229	Mouse	HEK293	Mouse LILRB4 / CD85k / ILT3 Protein, His Tag (MALS verified)
CDK-M82E3	Mouse	HEK293	Biotinylated Mouse LILRB4 / CD85k / ILT3 Protein, His,Avitag™ (MALS verified)

총 수량11

LILRB4분자 배경

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

LILRB4분자 별명

LILRB4,ILT3,LIR5,CD85K,HM18

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
MK-0482	MK-0482	Phase 2 Clinical	Merck Sharp & Dohme Corp	Carcinoma, Non-Small-Cell Lung; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Neoplasms; Sarcoma; Squamous Cell Carcinoma of Head and Neck	상세
IO-202	IO-202	Phase 1 Clinical	Yiming Biomedical Technology (Hangzhou) Co Ltd	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Solid tumours	상세
anti-ILT3 CAR T-cell therapy (Carbiogene Therapeutics)		Phase 1 Clinical	Carbiogene Therapeutics Co Ltd	Leukemia, Myeloid, Acute	상세
YTS-104	LILRB4 STAR-T; YTS-104	Phase 1 Clinical	Beijing Qingyi Taike Pharmaceutical Technology Co Ltd, China Immunotech Co Ltd	Leukemia, Myeloid	상세
BND-35	BND-35; BND35	Phase 1 Clinical	Biond Biologics Ltd	Neoplasms; Solid tumours	상세
NGM-831	NGM-831	Phase 1 Clinical	NGM Biopharmaceuticals Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	상세
anti-ILT3 CAR-T Therapy(Carbiogene)		Phase 1 Clinical	Carbiogene Therapeutics Co Ltd	Leukemia, Myeloid, Acute	상세