언어 선택

LAG-3

LAG-3 분자 정보

영어 이름	Lymphocyte activation gene 3 protein	시판 약물 수	1
임상 약물 수	31	표적 별명	Lymphocyte activation gene 3 protein，LAG3，Lymphocyte Activating 3，Lymphocyte-Activation Gene 3，CD223 Antigen，Protein FDC，CD223，LAG-3，FDC，sLAG-3
최고 연구 개발 단계	Approved

영어 이름	Lymphocyte activation gene 3 protein
표적 별명	Lymphocyte activation gene 3 protein，LAG3，Lymphocyte Activating 3，Lymphocyte-Activation Gene 3，CD223 Antigen，Protein FDC，CD223，LAG-3，FDC，sLAG-3
시판 약물 수	1
임상 약물 수	31
최고 연구 개발 단계	Approved

LAG-3 제품 목록

속성
Protein (20)Cell (1)Antibody (1)
제품 라이브러리
온라인 (22)
종
Human (10)Rat (1)Mouse (5)Cynomolgus (5)Canine (1)
태그
His Tag (7)Fc Tag (3)Mouse IgG Fc Tag (3)Mouse IgG Fc Tag & Avi Tag (1)Llama IgG Fc Tag (1)Fc Tag & Avi Tag (2)His Tag & Avi Tag (3)- (2)
마커
Unconjugated (13)Biotin-labeled (7)- (1)PE Labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT LA3-H5222	Human	HEK293	Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
HOT LA3-H5255	Human	HEK293	Human LAG3 / CD223 Protein, Fc Tag, low endotoxin (MALS verified)
HOT LA3-H82E9	Human	HEK293	Biotinylated Human LAG-3 / CD223 Protein, His,Avitag™ (MALS verified)
HOT LA3-H82F3	Human	HEK293	Biotinylated Human LAG-3 / CD223 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
HOT LA3-M52H5	Mouse	HEK293	Mouse LAG-3 / CD223 Protein, His Tag (MALS verified)
LA3-H525c	Human	HEK293	Human LAG-3 / CD223 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
LA3-H52Aa	Human	HEK293	Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
LA3-H52H3	Human	HEK293	Human LAG-3 / CD223 Protein, His Tag (MALS verified)
LA3-H82Fb	Human	HEK293	Biotinylated Human LAG-3 / CD223 Protein, Fc,Avitag™ (MALS verified)
LA3-HP2H4	Human	HEK293	PE-Labeled Human LAG-3 / CD223 Protein, His TagStar Staining

총 수량22

LAG-3분자 배경

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

LAG-3분자 별명

LAG3,CD223,FDC

라이선싱 협력

프로젝트 이름	약물 유형	치료 영역	적응증	단계	권리 지역
LAG-3 mAb	Monospecific antibody	Oncology/Cancer	Advanced solid tumor	Phase I	Global

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Relatlimab	ONO-4482; BMS-986016	Phase 3 Clinical	Bristol-Myers Squibb Company	Adenocarcinoma; Brain metastases; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Chordoma; Colorectal Neoplasms; Esophageal Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; Hodgkin Disease; Large intestine neoplasm; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Male Urogenital Diseases; Melanoma; Microsatellite instability-high cancer; Multiple Myeloma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Sarcoma; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms; Uveal melanoma	상세
Fianlimab	REGN-3767	Phase 3 Clinical	Regeneron Pharmaceuticals Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Head and Neck Neoplasms; Melanoma; Neoplasms; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	상세
Tebotelimab	PD-1 X LAG-3; MGD-013	Phase 3 Clinical	Macrogenics Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	상세
Mavezelimab/Pembrolizumab	MK-4280A; MK-4820A	Phase 3 Clinical	Merck Sharp & Dohme Corp	Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Hodgkin Disease; Neoplasm Metastasis; Small Cell Lung Carcinoma; Solid tumours	상세
SHR-1802	SHR-1802	Phase 2 Clinical	Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd	Neoplasms; Solid tumours	상세
Tobemstomig	RO-7247669	Phase 2 Clinical	F. Hoffmann-La Roche Ltd	Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Esophageal Squamous Cell Carcinoma; Liver Neoplasms; Melanoma; Solid tumours	상세
Alcestobart	LBL-007	Phase 2 Clinical	Leads Biolabs Inc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Lymphoma; Melanoma; Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
Negalstobart	IBI-110	Phase 2 Clinical		Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Hematologic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Nasopharyngeal Carcinoma; Neoplasms; Skin Melanoma; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck	상세
Mavezelimab	MK-4280	Phase 2 Clinical	Merck Sharp & Dohme Corp	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Small Cell Lung Carcinoma	상세
Ieramilimab	IMP-701; LAG-525	Phase 2 Clinical	Immutep	Esophageal adenocarcinoma; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Persistent Fetal Circulation Syndrome; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
Miptenalimab	BI-754111	Phase 2 Clinical	C.H. Boehringer Sohn Ag & Co. Kg	Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Solid tumours	상세
AK-129	AK-129	Phase 2 Clinical		Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Hodgkin Disease; Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	상세
HLX-26	HLX-26	Phase 2 Clinical		Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Lymphoma; Solid tumours	상세
GLS-012	GLS-012	Phase 2 Clinical	Harbin Gloria Pharmaceuticals Co Ltd	Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours	상세
EMB-02	EMB-02	Phase 2 Clinical	Shanghai Epimab Biotherapeutics, Inc	Solid tumours	상세
DNV-3	DNV-3; DNV3	Phase 2 Clinical	Zhejiang Shimai Pharmaceutical Co Ltd	Lymphoma; Melanoma; Neoplasms; Skin Neoplasms; Solid tumours	상세
KL-A289	KL-A289	Phase 1 Clinical	Anyuan Pharmaceutical Technology (Shanghai) Co Ltd, Sichuan Kelun-Biotech Biopharmaceutical Co Ltd	Solid tumours	상세
Bavunalimab	XmAb-22841; XmAb-841	Phase 1 Clinical	Xencor Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Nasopharyngeal Carcinoma; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	상세
IMP-761	IMP-761	Phase 1 Clinical	Immutep	Autoimmune Diseases	상세
Sym-022	Sym-022; Sym022; S95017	Phase 1 Clinical	Symphogen A/S	Lymphoma; Neoplasm Metastasis; Solid tumours	상세
MIL-98	MIL-98	Phase 1 Clinical	Beijing Mabworks Biotech Co Ltd	Breast Neoplasms; Lymphoma; Melanoma; Solid tumours	상세
AN-8025	AN-8025	Phase 1 Clinical	Hangzhou Adlai Nortye Biopharma Co Ltd	Solid tumours	상세
ABL-501	ABL-501	Phase 1 Clinical	Abl Bio Inc	Solid tumours	상세
TQB-2252	TQB-2252; TQB2252	Phase 1 Clinical	Chia Tai Tianqing (Guangzhou) Pharmaceutical Co Ltd	Neoplasms; Solid tumours	상세
AK-137	AK137; AK-137	Phase 1 Clinical		Neoplasms	상세
SSGJ-709	SSGJ-709; SSGJ709	Phase 1 Clinical	Shenyang Sunshine Pharmaceutical Co Ltd	Neoplasms; Solid tumours	상세
JY-03	JY03; JY-03	Phase 1 Clinical	Beijing Eastern Biotech Co Ltd, Beijing Jingyitaixiang Technology Development Co Ltd	Solid tumours	상세
ZGGS-15	ZGGS15; ZGGS-15	Phase 1 Clinical	Suzhou Zelgen Biopharmaceuticals Co Ltd	Solid tumours	상세
IBI-323(Innovent Biologics)	IBI-323	Phase 1 Clinical		Neoplasms; Solid tumours	상세
Encelimab	TSR-033; TSR 033; TSR033; GSK-4074386	Phase 1 Clinical	Anaptysbio Inc	Neoplasms	상세
68Ga-DOTA-hLAG-3		Clinical	The First Affiliated Hospital Of Xiamen University	Neoplasms	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Nivolumab/Relatlimab	BMS-986213; BMS-936558/BMS-986016	Approved	Bristol-Myers Squibb Company	OPDUALAG	United States	Melanoma	Bristol-Myers Squibb Company	2022-03-18	Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Skin Melanoma; Solid tumours; Stomach Neoplasms	상세

제품 리뷰

N***r2022-11-08
0사람들이 좋아합니다
Biotinylated Human LAG-3 / CD223 Protein, His,Avitag™ (MALS verified)
Ordered this reagent for a binding ELISA performed for a client. Client had questions about extending the reagent expiry and getting extra documentation provided for a GMP project. Acros customer service was great in answering all of my questions and providing documentation within just a few mins. I was provided with the COA and a memo ensuring the expiry could be extended from data that Acros had collected. I was also able to talk to other scientists on the technical side of their customer services and ensure that what I was relaying to the client was accurate. Really helped out on this project and the client was very happy! Thank you Acros!
1***12019-11-07
1사람들이 좋아합니다
Human LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)
I purchased Acro's protein many times for experiments. LAG3 was used mostly, and the titer after immunization can reach more than 100,000. It is a very good product.
1***92019-10-11
0사람들이 좋아합니다
Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
We purchased ACRO's Human LAG3-mFc protein, and we tested its affinity with the antibody on Biacore T200. The results showed that the affinity was within the normal range, and the protein bioactivity is very good!