언어 선택

KLRG1

KLRG1 분자 정보

영어 이름	Killer cell lectin-like receptor subfamily G member 1	시판 약물 수	0
임상 약물 수	1	표적 별명	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
최고 연구 개발 단계	Phase 3 Clinical

영어 이름	Killer cell lectin-like receptor subfamily G member 1
표적 별명	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 3 Clinical

KLRG1 제품 목록

속성
Protein (5)
제품 라이브러리
온라인 (5)
종
Human (1)Mouse (1)Cynomolgus (3)
태그
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
마커
Unconjugated (4)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT KL1-H5249	Human	HEK293	Human KLRG1 Protein, His Tag
HOT KL1-M5249	Mouse	HEK293	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)
HOT KL1-C5243	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, His Tag (SPR verified)
HOT KL1-C5269	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)
KL1-C82Q4	Cynomolgus	HEK293	Biotinylated Cynomolgus KLRG1 Protein, Avitag™,His Tag

총 수량5

KLRG1분자 배경

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.