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Klotho beta

Klotho beta Overview

English Name	Klotho beta	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Highest Development Stage	Phase 2 Clinical

English Name	Klotho beta
Target Synonym	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

Klotho beta Product List

Product Category
Protein (7)
Product Status
Launched (7)
Species
Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Human (2)Rhesus macaque (1)
Tag
His Tag (7)
Conjugate
Unconjugated (5)Biotin-labeled (2)

Cat. No.	Species	Host	Product Description
HOT KLB-H52H4	Human	HEK293	Human Klotho beta / KLB Protein, His Tag
HOT KLB-M52H7	Mouse	HEK293	Mouse Klotho beta / KLB Protein, His Tag
HOT KLB-R52H8	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag
KLB-H82H3	Human	HEK293	Biotinylated Human Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)
KLB-M52H3	Mouse	HEK293	Biotinylated Mouse Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) (HPLC verified)
KLB-R52H6	Rat	HEK293	Rat Klotho beta / KLB Protein, His Tag
KLB-R82H3	Rhesus macaque	HEK293	Biotinylated Rhesus macaque Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)

Total: 7

Klotho beta Background

KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.

Klotho beta Synonyms

betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NGM-313	NGM-313; MK-3655	Phase 2 Clinical	NGM Biopharmaceuticals Inc	Hepatitis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	Details
JMT-202	JMT202; JMT-202	Phase 2 Clinical	Shanghai Jmt-Bio Inc	Hypertriglyceridemia	Details
DR-10624	DR-10624; DR10624	Phase 2 Clinical	Zhejiang Doer Biologics Corp	Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight	Details