Integrin alpha V beta 6

Integrin alpha V beta 6

Integrin alpha V beta 6 분자 정보

Molecule Name
Integrin alpha-V/beta-6
Drug Development Progress
임상 약물 수6
시판 약물 수0
최고 연구 개발 단계Phase 2 Clinical
표적 별명
분자 배경
Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Integrin alpha V beta 6 제품 목록

Species
  • Human(3)
  • Cynomolgus(2)
  • Mouse(2)
  • Mouse & Human(1)
  • Rat(1)
Tag
  • His Tag(6)
  • His Tag & Avi Tag(3)
Host
  • HEK293(9)
Conjugate
  • Unconjugated(6)
  • Biotin-labeled(3)
Grade
  • RUO(9)
Low Endotoxin
  • Yes(4)
  • No(5)
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
Integrin alpha V beta 6
Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free
Human
HEK293
MALSSDS-PAGE
SPR

$1390.00

250ug
Integrin alpha V beta 6
Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPR

$485.00

100ug
Integrin alpha V beta 6
Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISABLI

$485.00

100ug
Integrin alpha V beta 6
Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISASPR

$485.00

100ug
Integrin alpha V beta 6
HOTAvitag
IT6-H82E4
Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$435.00

25ug
Integrin alpha V beta 6
Avitag
IT6-C82E3
Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free
Cynomolgus
HEK293
SDS-PAGE
ELISA

$360.00

25ug
Integrin alpha V beta 6
Mouse & Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Mouse & Human
HEK293
MALSSDS-PAGE
ELISA

$485.00

100ug
Integrin alpha V beta 6
Avitag
IT6-M82W9
Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Integrin alpha V beta 6
Rat Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)
Rat
HEK293
MALSSDS-PAGE
ELISA

$420.00

100ug
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FAQ

How should αVβ6 cross-species binding be assessed before animal studies?

Screen against human αVβ6, then compare the homolog from the intended model, such as cynomolgus, mouse, or rat. Use matched heterodimer formats and assay conditions to avoid construct-driven differences.

When should recombinant αVβ6 protein and an αVβ6 stable cell line be used together?

Recombinant αVβ6 supports controlled affinity and biochemical inhibition assays. A stable cell line then confirms recognition of membrane-displayed αVβ6 and reveals accessibility or avidity effects.

Why is a MALS-verified αVβ6 heterodimer important for inhibitor screening?

The binding surface depends on the assembled αV and β6 subunits. SEC-MALS helps confirm the expected molecular assembly and detect aggregation that could distort multivalent binding signals.

How should RGD-ligand and divalent-cation conditions be controlled in αVβ6 assays?

αVβ6 recognition is RGD- and conformation-dependent, and Ca²⁺, Mg²⁺, or Mn²⁺ can alter apparent affinity. Keep ligand source, cation composition, and chelator content constant across candidates and lots.

How can direct αVβ6 blockade be distinguished from downstream TGF-β pathway inhibition?

Measure disruption of the αVβ6–latent TGF-β1 interaction first, using a binding assay such as TR-FRET. Follow with a cell-based TGF-β readout to determine whether pathway inhibition is consistent with direct target blockade.
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