언어 선택

Integrin alpha D beta 2

Integrin alpha D beta 2 분자 정보

영어 이름	Integrin alpha-4	시판 약물 수	0
임상 약물 수	3	표적 별명	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Integrin alpha-4
표적 별명	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 2 Clinical

Integrin alpha D beta 2 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
IT2-H53W6	Human	CHO	Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free

총 수량1

Integrin alpha D beta 2분자 배경

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.

Integrin alpha D beta 2분자 별명

Integrin alpha D beta 2,ITGAD & ITGB2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Avicursen	TV-1102; ATL/TV-1102; ATL-1102; ISIS-107248	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Multiple Sclerosis; Muscular Dystrophy, Duchenne	상세
BIIB-107 (Biogen)	BIIB-107	Phase 1 Clinical	Biogen Inc	Multiple Sclerosis	상세
ELND-004	ELND-004	Phase 1 Clinical	Perrigo Company Plc	Autoimmune Diseases	상세