언어 선택

Integrin alpha 4 beta 7

Integrin alpha 4 beta 7 분자 정보

영어 이름	Integrin alpha-4/beta-7	시판 약물 수	4
임상 약물 수	14	표적 별명	LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1
최고 연구 개발 단계	Approved

영어 이름	Integrin alpha-4/beta-7
표적 별명	LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1
시판 약물 수	4
임상 약물 수	14
최고 연구 개발 단계	Approved

Integrin alpha 4 beta 7 제품 목록

속성
Protein (4)Kits (2)Cell (1)
제품 라이브러리
온라인 (7)
종
Human (5)Cynomolgus (2)
태그
His Tag (2)- (3)His Tag & Avi Tag (2)
마커
Unconjugated (2)- (3)Biotin-labeled (2)

제품 번호	종	발현 시스템	제품 설명
CHEK-ATP243	Human	HEK293	HEK293/Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Stable Cell Line
EP-155	Human	-	Integrin α 4 β 7 : MAdCAM-1 [Biotinylated] Inhibitor Screening ELISA Kit
AI Compatible FRT-P013	Human	-	Human Integrin α4β7 / MAdCAM-1 Inhibitor Screening Kit (TR-FRET)
IT7-H52W4	Human	HEK293	Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified)
IT7-H82W4	Human	HEK293	Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT7-C52W4	Cynomolgus	HEK293	Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
IT7-C82W3	Cynomolgus	HEK293	Biotinylated Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

총 수량7

Integrin alpha 4 beta 7분자 배경

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Integrin alpha 4 beta 7분자 별명

Integrin alpha 4 beta 7,ITGA4&ITGB7

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Etrolizumab	PRO-145223; rhuMAb-Beta7; R-7413; RG-7413	Phase 3 Clinical	Genentech Inc	Colitis, Ulcerative; Crohn Disease	상세
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	상세
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	상세
Natalizumab biosimilar (GENERIUM Pharmaceuticals)	GNR-093	Phase 3 Clinical	Generium Pharmaceuticals	Multiple Sclerosis	상세
LY-4268989	MORF-057; LY-4268989; LY4268989	Phase 2 Clinical	Morphic Therapeutic Inc	Colitis, Ulcerative; Crohn Disease	상세
EA-1080	EA-1080; NSHO-101	Phase 2 Clinical	Ea Pharma	Colitis, Ulcerative; Crohn Disease; Inflammatory Bowel Diseases	상세
PN-10943	PN-10943-A; PN-10943; PN-943	Phase 2 Clinical	Protagonist Therapeutics Inc	Colitis, Ulcerative	상세
Emvistegrast	GS-1427	Phase 2 Clinical	Gilead Sciences Sl	Colitis, Ulcerative; Inflammatory Bowel Diseases	상세
ABBV-466		Phase 2 Clinical	Abbvie Inc	Crohn Disease	상세
SPY-001	SPY001; SPY-001; PR-011; PR011; SPY001-001	Phase 2 Clinical	Paragon Therapeutics Inc	Colitis; Colitis, Ulcerative; Inflammatory Bowel Diseases	상세
Trosunilimab	ABBV-382	Phase 2 Clinical	Abbvie Inc	Crohn Disease; HIV Infections	상세
PTG-100	PTG-100	Phase 1 Clinical	Protagonist Therapeutics Inc	Celiac Disease; Colitis, Ulcerative	상세
NSHO-102	NSHO-102	Phase 1 Clinical	Ensho Therapeutics Inc	Inflammatory Bowel Diseases	상세
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Carotegrast methyl	AJM-300	Approved	Ea Pharma, Eisai Co Ltd	Carogra	Japan	Colitis, Ulcerative	Ea Pharma Co Ltd	2022-03-28	Colitis, Ulcerative	상세
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	상세
Natalizumab biosimilar (Polpharma Biologics)	PB-006; DST-356A1	Approved	Polpharma Biologics Sa	Tyruko	United States	Multiple Sclerosis; Crohn Disease	Sandoz Inc	2023-08-24	Crohn Disease; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting	상세
Natalizumab	BG-0002; TY-21.6; AN-10022; BG-00002; AN-100226; BG-0002-E	Approved	Biogen Inc, Perrigo Llc	Tysabri, Antegran, Antegren	United States	Crohn Disease; Multiple Sclerosis	Biogen Idec	2004-11-23	Arthritis, Rheumatoid; Crohn Disease; Demyelinating Diseases; Epilepsies, Partial; Graft vs Host Disease; Ischemic Stroke; Multiple Myeloma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myositis, Inclusion Body	상세