언어 선택

ILDR2

ILDR2 분자 정보

영어 이름	Immunoglobulin-like domain-containing receptor 2	시판 약물 수	0
임상 약물 수	1	표적 별명	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
최고 연구 개발 단계	Phase 1 Clinical

영어 이름	Immunoglobulin-like domain-containing receptor 2
표적 별명	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 1 Clinical

ILDR2 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
Fc Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
IL2-H5259	Human	HEK293	Human ILDR2 Protein, Fc Tag

총 수량1

ILDR2분자 배경

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.