IL-22 R alpha 1 분자 정보
Molecule Name
Interleukin-22 receptor
Drug Development Progress
임상 약물 수5
시판 약물 수0
최고 연구 개발 단계Phase 2 Clinical
표적 별명
분자 배경
Interleukin-22 receptor subunit alpha-1(IL22RA1) is a component of the receptor for IL20, IL22 and IL24.Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
IL-22 R alpha 1 제품 목록
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임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| Efmarodocokin alfa | RO-7021610; UTTR-1147A; RG-7880 | Phase 2 Clinical | Genentech Inc | Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Diabetic Foot; Graft vs Host Disease | 상세 |
| Temtokibart | ARGX-112; LEO-138559; LP-0145 | Phase 2 Clinical | Argenx Se, Leo Pharma Inc | Dermatitis, Atopic | 상세 |
| CK-0045 | CK-0045 | Phase 2 Clinical | Cytoki Pharma ApS | Diabetes Mellitus, Type 2; Obesity; Overweight | 상세 |
| Eflepedocokin alfa | F-652 | Phase 2 Clinical | Evive Biotech Ltd | Acute-On-Chronic Liver Failure; Coronavirus Disease 2019 (COVID-19); Enteritis; Enterocolitis, Necrotizing; Graft vs Host Disease; Hepatitis, Alcoholic; Pancreatitis | 상세 |
| ABBV-022 | ABBV-022 | Phase 1 Clinical | Abbvie Inc | Colitis, Ulcerative | 상세 |