언어 선택

IL-17B

IL-17B 분자 정보

영어 이름	Interleukin-17 receptor B	시판 약물 수	0
임상 약물 수	1	표적 별명	IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Interleukin-17 receptor B
표적 별명	IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 2 Clinical

IL-17B 제품 목록

속성
Protein (3)
제품 라이브러리
온라인 (3)
종
Human (2)Mouse (1)
태그
Fc Tag (1)Fc Tag & Avi Tag (2)
마커
Unconjugated (1)Biotin-labeled (2)

제품 번호	종	발현 시스템	제품 설명
ILB-H5257	Human	HEK293	Human IL-17B Protein, Fc Tag (MALS verified)
ILB-H82F1	Human	HEK293	Biotinylated Human IL-17B Protein, Fc,Avitag™ (MALS verified)
ILB-M82F3	Mouse	HEK293	Biotinylated Mouse IL-17B Protein, Fc,Avitag™ (MALS verified)

총 수량3

IL-17B분자 배경

IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.