언어 선택

IL-12B

IL-12B 분자 정보

영어 이름	Interleukin-12 subunit beta	시판 약물 수	8
임상 약물 수	2	표적 별명	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
최고 연구 개발 단계	Approved

영어 이름	Interleukin-12 subunit beta
표적 별명	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
시판 약물 수	8
임상 약물 수	2
최고 연구 개발 단계	Approved

IL-12B 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Human (3)Mouse (1)
태그
His Tag (1)Fc Tag (1)His Tag & Avi Tag (2)
마커
Unconjugated (2)Biotin-labeled (2)

제품 번호	종	발현 시스템	제품 설명
HOT NK2-H82E3	Human	HEK293	Biotinylated Human IL-12B / NKSF2 / p40 Protein, His,Avitag™
NK2-H5258	Human	HEK293	Human IL-12B / NKSF2 / p40 Protein, Fc Tag
NK2-H52H7	Human	HEK293	Human IL-12B / NKSF2 / p40 Protein, His Tag
NK2-M82E5	Mouse	HEK293	Biotinylated Mouse IL-12B / NKSF2 / p40 Protein, His,Avitag™ (MALS verified)

총 수량4

IL-12B분자 배경

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B분자 별명

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
RO-7837195	RO-7837195; RO7837195	Phase 2 Clinical	Genentech Inc	Colitis, Ulcerative	상세
PF-07261271	RG-6730; PF-07261271	Phase 2 Clinical	Pfizer Inc	Inflammatory Bowel Diseases	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Ustekinumab biosimilar (Bio-Thera)	BAT-2206	Approved	Bio-Thera Solutions Ltd	STARJEMZA, Usymro	United States	Plaque psoriasis; Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic	Bio-Thera Solutions Ltd	2025-05-22	Arthritis, Psoriatic; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세
Ustekinumab	C-340; CNTO-1275	Approved	Johnson & Johnson Innovative Medicine	Stelara, 喜达诺	United States	Plaque psoriasis	Janssen Biotech Inc	2009-09-25	Arthritis, Juvenile; Arthritis, Psoriatic; Colitis, Ulcerative; Common Variable Immunodeficiency; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Hidradenitis Suppurativa; Ichthyosis; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Multiple Sclerosis; Palmoplantar pustulosis; Pediatric Crohn's disease; Plaque psoriasis; Polymyositis; Pouchitis; Psoriasis; Sjogren's Syndrome; Spondylitis, Ankylosing; Takayasu Arteritis; Type I Leukocyte Adhesion Defect; Uveitis	상세
Ebdarokimab	AK-101; AK101	Approved		爱达罗	Mainland China	Plaque psoriasis	Zhongshan Akeso Biopharma Co Ltd	2025-04-15	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세
Ustekinumab Biosimilar(Celltrion)	CT-P43	Approved	Celltrion Inc	Steqeyma, Steqeyma IV, Qoyvolma	Canada	Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis	Celltrion Inc	2024-08-01	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세
Ustekinumab biosimilar (Biocon)	Bmab 1200	Approved	Biocon Biologics Ltd	Yesintek	United States	Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic	Biocon Biologics Inc	2024-11-29	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세
Ustekinumab biosimilar (Alvotech)	AVT04; AVT-04	Approved	Alvotech hf	Jamteki, Uzpruvo, SELARSDI™, JamtekiTM, Ustekinumab BS (F)	Japan	Arthritis, Psoriatic; Psoriasis	Fuji Pharma Co Ltd	2023-09-25	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세
Ustekinumab biosimilar (Samsung Bioepis)	SB-17; SB17	Approved	Samsung Bioepis Co Ltd	Pyzchiva, Eksunbi	EU	Crohn Disease; Colitis, Ulcerative	Samsung Bioepis Nl Bv	2024-04-19	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Diseases; Inflammation; Plaque psoriasis; Psoriasis; Rheumatic Diseases; Skin Diseases	상세
Ustekinumab biosimilar (Amgen)	ABP-654; AMG-654	Approved	Amgen Inc	Wezlana, WEZLANA, wezenla, WEZENLA	United States	Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis	Amgen Inc	2023-10-31	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	상세