IL-1 RAcP 분자 정보
Molecule Name
Interleukin-1 receptor accessory protein
분자 별명
IL1RAP,IL-1RAcP,C3orf13,IL1R3
Drug Development Progress
임상 약물 수8
시판 약물 수0
최고 연구 개발 단계Phase 2 Clinical
표적 별명
Interleukin-1 receptor 3，IL-1RAcP，IL-1 receptor accessory protein，IL-1R-3，C3orf13，Interleukin 1 Receptor Accessory Protein，IL1R3，Interleukin-1 Receptor Accessory Protein Beta，IL-1R3
분자 배경
Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
IL-1 RAcP 제품 목록
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임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| Nidanilimab | CAN-04 | Phase 2 Clinical | Lund University Foundation | Biliary Tract Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Transitional Cell; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Sarcoidosis, Pulmonary; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms | 상세 |
| CCTx-001 | CCTx-001 | Phase 2 Clinical | Advesya SAS | Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | 상세 |
| SAR-445399 | SAR-445399 | Phase 2 Clinical | Sanofi | Hidradenitis Suppurativa; Immune System Diseases; Inflammation | 상세 |
| IBI-3011 | IBI-3011; IBI3011 | Phase 1 Clinical | Arthritis, Gouty; Gout | 상세 | |
| Gene modified anti-IL1RAP Chimeric Antigen Receptor T Cells therapy(Shanghai Zhongshan Hospital) | Phase 1 Clinical | Shanghai Zhongshan Hospital | Carcinoma, Hepatocellular | 상세 | |
| AK-135 | AK135; AK-135 | Phase 1 Clinical | Peripheral Nervous System Diseases | 상세 | |
| DXP-106 | DXP-106; DXP106 | Phase 1 Clinical | Singlomics Biopharmaceuticals Co Ltd | Neoplasms; Solid tumours | 상세 |
| GSK-3903371 | GSK-3903371; BOS-371 | Clinical | Glaxosmithkline Plc | Neoplasms | 상세 |