IFN-alpha/beta R1 Overview
Molecule Name
Interferon-alpha/beta receptor alpha chain
Synonyms
IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs5
Highest Development StageApproved
Target Synonym
IFNBR，IFN-Alpha-REC，Beta-Type Antiviral Protein，IFNAR，Cytokine Receptor Class-II Member 1，Interferon Receptor 1，IFNAR1，Interferon Alpha/Beta Receptor 1，Interferon Alpha And Beta Receptor Subunit 1，Type I Interferon Receptor 1，Interferon (Alpha， Beta And Omega) Receptor 1，Alpha-Type Antiviral Protein，IFN-Alpha/Beta Receptor 1，AVP，Interferon-Beta Receptor 1，IFRC，IFN-R-1，CRF2-1，Cytokine Receptor Family 2 Member 1，Interferon-Alpha/Beta Receptor Alpha Chain
Background
Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
IFN-alpha/beta R1 Product List
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Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Interferon beta (Toray/Daiichi Sankyo) | DL-8234 | Approved | Toray Industries Inc | Feron | Japan | Medulloblastoma; Melanoma; Hepatitis C; Astrocytoma; Glioblastoma; Hepatitis B | null | 1985-04-01 | Astrocytoma; Glioblastoma; Hepatitis B; Hepatitis C; Medulloblastoma; Melanoma | Details |
| Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) | Approved | Harbin Pharmaceutical Group Holding Co Ltd | 里亚美, 利分能 | Mainland China | Hepatitis, Viral, Human; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Condylomata Acuminata; Varicella Zoster Virus Infection | Harbin Pharmaceutical Group Pharmaceutical Co Ltd | 1996-01-01 | Condylomata Acuminata; Hepatitis, Viral, Human; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Varicella Zoster Virus Infection | Details | |
| Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) | Approved | Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd | Fu Li Sheng | Condylomata Acuminata; Hepatitis; Herpes Zoster; Leukemia, Hairy Cell; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Multiple Myeloma | Details | |||||
| Anifrolumab | MEDI-546; MDX-1333 | Approved | Medarex Inc, Medimmune Llc | SAPHNELO | United States | Lupus Erythematosus, Systemic | Astrazeneca Ab | 2021-07-30 | Atherosclerosis; Autoimmune Diseases; Cardiovascular Diseases; Dermatomyositis; Hidradenitis; Hidradenitis Suppurativa; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Lupus Nephritis; Myositis; Polymyositis; Scleroderma, Systemic; Sjogren's Syndrome; Vitiligo | Details |
| Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) | Approved | Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma | 莱福隆 | Mainland China | Virus Diseases; Neoplasms | Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma | 1999-01-01 | Neoplasms; Virus Diseases | Details |