언어 선택

IDH1

IDH1 분자 정보

영어 이름	Isocitrate dehydrogenase [NADP] cytoplasmic	시판 약물 수	3
임상 약물 수	11	표적 별명	IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic
최고 연구 개발 단계	Approved

영어 이름	Isocitrate dehydrogenase [NADP] cytoplasmic
표적 별명	IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic
시판 약물 수	3
임상 약물 수	11
최고 연구 개발 단계	Approved

IDH1 제품 목록

속성
Protein (2)
제품 라이브러리
온라인 (2)
종
Human (2)
태그
His Tag (2)
마커
Unconjugated (2)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
ID1-H51H6	Human	E. coli	Human IDH1 Protein, His Tag (active enzyme, MALS verified)
ID1-H51H8	Human	E. coli	Human IDH1 (R132C) Protein, His Tag (MALS verified)

총 수량2

IDH1분자 배경

The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‑ketoglutarate，2-HG is elevated in several tumor types, including a subset of AMLs.

IDH1분자 별명

IDH1,PICD,IDP

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Safusidenib	DS-1001b; DS-1001; AB-218	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Astrocytoma; Biliary Tract Neoplasms; Glioblastoma; Glioma; Oligodendroglioma; Solid tumours	상세
Ranosidenib	HMPL-306	Phase 3 Clinical		Glioma; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Solid tumours	상세
TQB-3454	TQB-3454; CT-2755	Phase 3 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Bile Duct Neoplasms; Biliary Tract Neoplasms; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Solid tumours	상세
MT-001	MT-001; MT001	Phase 2 Clinical	Zhejiang Meton Pharmaceutical Co Ltd	Neoplasms; Solid tumours	상세
BAY-1436032	BAY-1436032	Phase 1 Clinical	Bayer AG	Leukemia, Myeloid, Acute; Solid tumours	상세
IDH-305	IDH-305	Phase 1 Clinical	Novartis Pharma Ag	Glioma; Leukemia, Myeloid, Acute; Neoplasms	상세
IDH1/2 inhibitor (Eli Lilly)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	상세
BPI-221351	BPI-221351	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Glioma; Solid tumours	상세
KY-100001	KY-100001	Phase 1 Clinical	Kpc Pharmaceuticals Inc	Solid tumours	상세
HH-2301	HH-2301; HH2301	Phase 1 Clinical	ShangHai HaiHe Biopharma Co Ltd	Biliary Tract Neoplasms; Chondrosarcoma; Glioma; Solid tumours	상세
LY-3410738	LY-3410738	Phase 1 Clinical	Eli Lilly And Company	Cholangiocarcinoma; Chondrosarcoma; Glioma; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Myeloproliferative Disorders; Solid tumours	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Ivosidenib	CS-3010; S-95031; CS 3010; AG-120	Approved	Agios Pharmaceuticals Inc	拓舒沃, Tidhesco, Tibsovo, TIBSOVO, Tuoshuvo, Tosuvo	United States	Leukemia, Myeloid, Acute	Servier Pharmaceuticals Llc	2018-07-20	Bile Duct Neoplasms; Cholangiocarcinoma; Chondrosarcoma; Ependymoma; Glioma; Hematologic Neoplasms; Hepatic Insufficiency; Hepatoblastoma; Histiocytosis, Langerhans-Cell; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Medulloblastoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Sarcoma, Myeloid; Solid tumours; Wilms Tumor	상세
Vorasidenib	AG-881; AGI-23088; S-95032; S95032	Approved	Agios Pharmaceuticals Inc	VORANIGO	United States	Astrocytoma; Oligodendroglioma; Glioma	Servier Pharmaceuticals Llc, Laboratoires Servier	2024-08-06	Astrocytoma; Ganglioglioma; Glioblastoma; Glioma; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Liver Diseases; Liver Dysfunction; Myelodysplastic Syndromes; Oligodendroglioma	상세
Olutasidenib	FT-2102	Approved	Forma Therapeutics Holdings Inc	Rezlidhia	United States	Leukemia, Myeloid, Acute	Rigel Pharmaceuticals Inc	2022-12-01	Chondrosarcoma; Diarrhea; Irritable Bowel Syndrome; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes	상세