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HMGB1

HMGB1 Overview

English Name	High Mobility Group Protein B1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
Highest Development Stage	Phase 2 Clinical

English Name	High Mobility Group Protein B1
Target Synonym	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

HMGB1 Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Human (3)Mouse (1)
Tag
His Tag (2)Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (3)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HM1-H5220	Human	HEK293	Human HMGB1 Protein, His Tag, low endotoxin
HM1-H5255	Human	HEK293	Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
HM1-H82E3	Human	HEK293	Biotinylated Human HMGB1 Protein, His,Avitag™
HM1-M52H6	Mouse	HEK293	Mouse HMGB1 Protein, His Tag (MALS verified)

Total: 4

HMGB1 Background

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

HMGB1 Synonyms

HMGB1,HMG1,HMG3,SBP-1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
SB-17170	SB-17170	Phase 2 Clinical	Spark Biopharma Inc	Drug-Related Side Effects and Adverse Reactions; Idiopathic Pulmonary Fibrosis; Solid tumours	Details