HMGB1 Overview
Molecule Name
High Mobility Group Protein B1
Synonyms
HMGB1,HMG1,HMG3,SBP-1
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
Background
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
HMGB1 Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| SB-17170 | SB-17170 | Phase 2 Clinical | Spark Biopharma Inc | Drug-Related Side Effects and Adverse Reactions; Idiopathic Pulmonary Fibrosis; Solid tumours | Details |