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HLA-A*0301 & B2M & gp100 (ALLAVGATK)

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HLA-A*0301 & B2M & gp100 (ALLAVGATK)분자 배경

Glycoprotein 100, is also well known as gp100 and Melanocyte protein PMEL. This antigen is a melanocyte-specific type I transmembrane glycoprotein and composed of 661 amino acids. Glycoprotein 100 is related to the tumor regression in metastatic melanoma patients after adoptive therapy, by which its epitopes being recognized by tumor lymphocytes and T-cells. The gp100280–288(YLEPGPVTA) was originally shown to be recognized by HLA-A*0301 tumor-infiltrating lymphocytes from melanoma patients, and therefore it is widely been studied in TCR -T studies. The Human HLA-A*0301 gp100 (YLEPGPVTA) complex protein is a complex of HLA-A*0301 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
PRT-001	PRT-001	Phase 3 Clinical	Particle Therapeutics	Hypoglycemia	상세
Retatrutide	LY-3437943	Phase 3 Clinical	Eli Lilly And Company	Diabetes Mellitus, Type 2; Atherosclerosis; Renal Insufficiency; Sleep Apnea, Obstructive; Hepatic Insufficiency; Osteoarthritis, Knee; Cardiovascular Diseases; Renal Insufficiency, Chronic; Obesity; Overweight	상세
Survodutide	BI-456906; BI-456909	Phase 3 Clinical	Zealand Pharma A/S	Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Renal Insufficiency; Liver Cirrhosis; Fibrosis; Hepatitis; Liver Diseases; Obesity; Overweight; Diabetes Mellitus	상세
Pemvidutide	ALT-801(Altimmune); SP-1373; VPD-107	Phase 2 Clinical	Velocity Pharmaceutical Development	Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Obesity; Overweight	상세
Efinopegdutide	JNJ-64565111; HM-12525A; JNJ-5111; MK-6024	Phase 2 Clinical	Hanmi Pharmaceutical Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Liver Diseases; Hepatic Insufficiency; Obesity; Kidney Failure, Chronic	상세
Efocipegtrutide	HM-15211	Phase 2 Clinical	Hanmi Pharmaceutical Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	상세
volagidemab	AMG-477; REMD-477	Phase 2 Clinical	Amgen Inc	Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose Intolerance; Insulin Resistance; Hyperglycemia; Diabetes Mellitus	상세
Isosteviol	ISV; STX-03	Phase 2 Clinical	Stevia Pharma	Diabetes Mellitus, Type 2	상세
Oxyntomodulin long-acting (Pharmsynthez/Xenetic Biosciences)		Phase 2 Clinical	Pharmsynthez, Xenetic Biosciences Inc	Diabetes Mellitus, Type 2; Obesity	상세
Pegapamodutide	WG4ID2U7FT; TT-401; LY-2944876; OPK-88003	Phase 2 Clinical	Eli Lilly And Company	Diabetes Mellitus, Type 2; Obesity	상세
IONIS-GCGRRx	IONIS-GCGRRx; ISIS-449884; ISISGCGRRx	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Diabetes Mellitus, Type 2	상세
Efpegerglucagon	HM-15136	Phase 2 Clinical	Hanmi Pharmaceutical Co Ltd	Congenital Hyperinsulinism; Diabetes Mellitus, Type 2	상세
AZD9550	AZD9550; AZD-9550	Phase 2 Clinical	Astrazeneca Plc	Metabolic Dysfunction-Associated Steatotic Liver Disease	상세
MWN-101	MWN-101	Phase 2 Clinical	Shanghai Minwei Biotechnology Co Ltd	Diabetes Mellitus, Type 2; Obesity; Overweight	상세
RBD-4988	RBD-4988	Phase 2 Clinical	Suzhou Ribo Life Science Co Ltd	Diabetes Mellitus, Type 2	상세
PB-718	PB-718	Phase 2 Clinical	Peg Bio Co Ltd	Congenital Hyperinsulinism; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight	상세
DD-01	DD-01	Phase 2 Clinical	D&D Pharmatech	Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Obesity; Overweight	상세
Cotadutide	MEDI-0382	Phase 2 Clinical	Medimmune Llc	Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Renal Insufficiency; Liver Cirrhosis; Hepatic Insufficiency; Diabetic Nephropathies; Renal Insufficiency, Chronic; Obesity; Diabetes Mellitus	상세
NN-9277	NN-9277; NNC-9204-1177	Phase 1 Clinical	Novo Nordisk A/S	Obesity; Overweight; Nutritional and Metabolic Diseases	상세
Glucagon (rDNA origin, Lilly)		Phase 1 Clinical	Eli Lilly And Company	Diabetes Mellitus, Type 1; Hypoglycemia; Insulin Resistance; Obesity	상세
Glucagon (Translational Research Institute for Metabolism and Diabetes, Florida)		Phase 1 Clinical	Translational Research Institute For Metabolism And Diabetes	Obesity	상세
NNC-92041706	NNC9204-1706; NNC-92041706; NN-9423; NNC-92041706-A	Phase 1 Clinical	Novo Nordisk A/S	Obesity; Nutritional and Metabolic Diseases	상세
PRT-003	PRT-003	Phase 1 Clinical	Particle Therapeutics		상세
SAR-441255	SAR-441255	Phase 1 Clinical	Sanofi	Overweight	상세
Glucagon/insulin human(Abvance Therapeutics)	ABV-100	Phase 1 Clinical	Abvance Therapeutics	Hypoglycemia	상세
PB-722	PB722; PB-722	Phase 1 Clinical	Peg Bio Co Ltd	Congenital Hyperinsulinism	상세
UBT-251	UBT-251; UBT251	Phase 1 Clinical	Lianbang Biotechnology (Zhuhai Hengqin) Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Obesity; Overweight	상세
TY-751	TY-751; TY751	Phase 1 Clinical		Metabolic Dysfunction-Associated Steatotic Liver Disease; Diabetes Mellitus, Type 2; Obesity; Diabetes Mellitus	상세
DA-1726	DA-1726	Phase 1 Clinical	Dong-A ST Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	상세
ZX-2021	ZX2021; ZX-2021	Phase 1 Clinical	Jiangsu Zhongxin Pharmaceutical Co Ltd	Diabetes Mellitus, Type 2; Obesity; Overweight	상세
DR-10624	DR-10624	Phase 1 Clinical	Zhejiang Doer Biologics Corp	Hypertriglyceridemia; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight; Diabetes Mellitus	상세
TB-001	TB-001; TB001	Phase 1 Clinical	Shenzhen Tuwei Anchuang Technology Development Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease; Liver Cirrhosis	상세
Human glucagon(Shanghai Duomirui)		Phase 1 Clinical	Shanghai Duomirui Biotechnology Co Ltd	Hypoglycemia	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Glucagon (rDNA origin, Novo Nordisk)	GL-G	Approved	Novo Nordisk A/S	GlucaGen, Glucagon G	United States	Gastrointestinal Diseases; Hypoglycemia	Novo Nordisk A/S	1998-06-22	Diabetes Mellitus, Type 1; Gastrointestinal Diseases; Hypoglycemia; Obesity	상세
Dasiglucagon	ZP-GA-1; ZP-4207	Approved	Zealand Pharma A/S	Zegalogue	United States	Hypoglycemia	Zealand Pharma Us Inc	2021-03-22	Diabetes Mellitus, Type 1; Congenital Hyperinsulinism; Hypoglycemia; Glucose Metabolism Disorders; Hyperinsulinism	상세
Glucagon	MP-123456B	Approved	Eli Lilly And Company	Ogluo, Baqsimi	EU	Hypoglycemia	Eli Lilly Nederland BV	1960-11-14	Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hypoglycemia	상세
Glucagon intranasal (Eli Lilly/Locemia Solutions)	AMG504-1; LY-900018	Approved	Amg Medical, Locemia Solutions						Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hypoglycemia; Diabetes Mellitus	상세
Glucagon (Xeris Pharmaceuticals)		Approved	Xeris Pharmaceuticals Inc	Gvoke	United States	Hypoglycemia	null	1960-01-01	Hypoglycemia; Hyperinsulinism	상세