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HLA-A*02:01 & B2M & Glypican 3

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HLA-A*02:01 & B2M & Glypican 3분자 배경

Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. The Human HLA-A*0201 Glycipan 3 (FVGEFFTDV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M and FVGEFFTDV peptide of the Glycipan 3 .

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Vactosertib	TEW-7197; EW-7197; NOV-1301	Phase 3 Clinical	Medpacto Inc	Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Myelodysplastic Syndromes; Carcinoma, Transitional Cell; Myeloproliferative Disorders; Osteosarcoma; Colorectal Neoplasms; Urologic Neoplasms; Esophageal adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Adenocarcinoma	상세
Bintrafusp alfa	M-7824; GSK-4045154; MSB-0011359C	Phase 3 Clinical	Merck Serono	Brain metastases; Cholangiocarcinoma; Breast Neoplasms; Microsatellite Instability; Vulvar Neoplasms; Sarcoma; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Thymus Neoplasms; Oropharyngeal Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Prostatic Neoplasms, Castration-Resistant; Lymphoma; Penile Neoplasms; Thymoma; Urogenital Neoplasms; Metastatic breast cancer; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Neoplasm Metastasis; Sarcoma, Kaposi; Neoplasms, Germ Cell and Embryonal; Stomach Neoplasms; Solid tumours; Hematologic Neoplasms; Head and Neck Neoplasms; Intestinal Neoplasms; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Vaginal Neoplasms; Carcinoma; Carcinoma, Renal Cell; Esthesioneuroblastoma, Olfactory; Anus Neoplasms; Biliary Tract Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Nose Neoplasms; Ganglioglioma; Papillomavirus Infections; Carcinoma, Trans	상세
Nisevokitug	NIS-793	Phase 3 Clinical	Xoma Corp	Kidney Neoplasms; Polycythemia Vera; Pancreatic Neoplasms; Myelodysplastic Syndromes; Breast Neoplasms; Colorectal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Adenocarcinoma; Thrombocythemia, Essential; Carcinoma, Hepatocellular	상세
SB-01 (Spine Biopharma)	SB-01	Phase 3 Clinical	Spine BioPharma Inc	Intervertebral disc disease; Low Back Pain	상세
Livmoniplimab	MGH-8; ARGX-115; AGRX-115; ABBV-151	Phase 3 Clinical	Argenx Se	Solid tumours; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular	상세
Dalutrafusp alfa	GS-1423; AGEN-1423	Phase 2 Clinical	Agenus Inc	Liver Neoplasms; Solid tumours; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal	상세
ZSP-1603	ZSP-1603	Phase 2 Clinical	Guangdong Zhongsheng Pharmaceutical Co Ltd	Ovarian Neoplasms; Liver Neoplasms; Solid tumours; Carcinoma, Renal Cell; Colonic Neoplasms; Idiopathic Pulmonary Fibrosis; Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung	상세
Nicousamide	XLF-III-43	Phase 2 Clinical	Institue Of Materia Medica Chinese Academy Of Medical Science	Hypertensive nephropathy; Diabetic Nephropathies	상세
Meflonidone hydrochloride		Phase 2 Clinical	Guangzhou Nanxin Pharma Co Ltd, Central South University	Diabetes Mellitus, Type 2; Diabetic Nephropathies	상세
Fluorofenidone	AKF-PD	Phase 2 Clinical	Dierepharma HK Ltd, Hainan Haiyao Co Ltd, Central South University	Liver Cirrhosis	상세
Cotsiranib	STP-705LU; STP-705LV; STP-705; STP-705L	Phase 2 Clinical	Sirnaomics, Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd	Liver Neoplasms; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Cholangiocarcinoma; Obesity, Abdominal; Keloid; Cicatrix, Hypertrophic; Carcinoma, Hepatocellular	상세
Yinfenidone Hydrochloride	HEC-585; HEC-00000585	Phase 2 Clinical	Hec Pharm Co Ltd	Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial	상세
YL-13027	YL-13027	Phase 2 Clinical	YL-Pharma	Solid tumours; Pancreatic Neoplasms	상세
Linavonkibart	SRK-181	Phase 1 Clinical	Scholar Rock	Neoplasms	상세
Charis-1000	Charis-1000; C 1K; C1K	Phase 1 Clinical		Breast Neoplasms	상세
HLX-6018	HLX-6018; HLX6018	Phase 1 Clinical		Idiopathic Pulmonary Fibrosis	상세
RO7496353	RO7496353; RO-7496353; SOF 10; RG6440; RG-6440	Phase 1 Clinical	Genentech Inc	Solid tumours; Stomach Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung	상세
JYB-1907	JYB-1907	Phase 1 Clinical	Jiangxi Jemincare Group Co Ltd	Solid tumours	상세
STP-707	STP-707	Phase 1 Clinical	Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd	Solid tumours; Liver Neoplasms; Liver Cirrhosis; Pulmonary Fibrosis; Cholangitis, Sclerosing	상세
PXS-64	PXS-64	Phase 1 Clinical		Multiple Sclerosis	상세
AVID-200	AVID-200; BMS-986416; AVID-200 DP	Phase 1 Clinical	Formation Biologics Corp	Solid tumours; Polycythemia Vera; Primary Myelofibrosis; Scleroderma, Diffuse; Thrombocythemia, Essential	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Tonogenchoncel-L	TG-C	Approved	Tissuegene	Invossa-K, Invossa	South Korea	Osteoarthritis	null	2017-07-01	Intervertebral Disc Degeneration; Osteoarthritis, Knee; Osteoarthritis	상세