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홈 페이지모든 분자GUCY2C
GUCY2C
GUCY2C 분자 정보
| 영어 이름 | Heat-stable enterotoxin receptor | 시판 약물 수 | 1 |
| 임상 약물 수 | 9 | 표적 별명 | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| 최고 연구 개발 단계 | Approved | ||
| 영어 이름 | Heat-stable enterotoxin receptor |
| 표적 별명 | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| 시판 약물 수 | 1 |
| 임상 약물 수 | 9 |
| 최고 연구 개발 단계 | Approved |
GUCY2C 제품 목록
- 속성
Protein (21)Cell (1)Antibody (1)
- 제품 라이브러리
온라인 (22)연구 중 (1)
- 종
Human (15)Mouse (4)Cynomolgus (3)Rabbit (1)
- 태그
Fc Tag (4)His Tag (13)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)- (2)
- 마커
Unconjugated (8)FITC Labeled (3)Biotin-labeled (4)PE Labeled (2)AF488 Labeled (1)APC Labeled (2)AF647 Labeled (1)AF555 Labeled (1)- (1)
총 수량23
- 1
- 2
- 3
GUCY2C분자 배경
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
GUCY2C분자 별명
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
라이선싱 협력
| 프로젝트 이름 | 약물 유형 | 치료 영역 | 적응증 | 단계 | 권리 지역 |
|---|---|---|---|---|---|
| Anti-GCC humanized antibody | Bispecific antibody | Oncology/Cancer | Solid Tumor | Preclinical | Global |
임상 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|
| anti-GUCY2C CAR T-cell therapy (Parasol Biotechnology/Anhui provincial cancer hospital) | Phase 1 Clinical | HeFei Parasol Biotech Co Ltd | Colorectal Neoplasms | 상세 | |
| anti-guanylyl cyclase C CAR-T cell therapy (Legend Biotech) | LCAR-G08T | Phase 1 Clinical | Legend Biotech Corp | Colorectal Neoplasms; Gastrointestinal Neoplasms | 상세 |
| HD-006 | HD006; HD-006 | Phase 1 Clinical | Huadao (Shanghai) Biopharma Co Ltd | Solid tumours | 상세 |
| REVO-UWD-01 | REVO-UWD-01; WD 01 | Phase 1 Clinical | Wondercel Therapeutics Co Ltd | Colorectal Neoplasms | 상세 |
| IM96 CAR-T cell Therapy | IM96 | Phase 1 Clinical | Imunopharm Technology Co Ltd | Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms | 상세 |
| GCC19CART | GCC19CART; LYL273; LYL-273 | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Colorectal Neoplasms; Rectal Neoplasms | 상세 |
| Gucy2c cart cell therapy (Innovative Cellular Therapeutics) | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Digestive System Neoplasms | 상세 | |
| XKDCT-080 | XKDCT-080 | Clinical | The Affiliated Hospital Of Qingdao University | Colonic Neoplasms; Solid tumours | 상세 |
| CT-080 | CT-080 | Clinical | Shenzhen Celconta Life Science Co Ltd | Solid tumours | 상세 |
시판 약물 정보
| 영어 이름 | 연구 코드 | 연구 개발 단계 | 회사 | 가장 빠른 브랜드 이름 | 가장 빠른 승인 국가 | 가장 빠른 적응증 | 가장 빠른 승인 회사 | 가장 빠른 승인 날짜 | 적응증 | 임상 시험 |
|---|---|---|---|---|---|---|---|---|---|---|
| Plecanatide | SP-304; GCRA | Approved | Synergy Pharmaceuticals Inc | Trulance | United States | Constipation; Chronic idiopathic constipation | Salix Pharmaceuticals | 2017-01-19 | Chronic idiopathic constipation; Constipation; Irritable Bowel Syndrome | 상세 |
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