언어 선택

Gremlin

Gremlin 분자 정보

영어 이름	Gremlin-1	시판 약물 수	0
임상 약물 수	2	표적 별명	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Gremlin-1
표적 별명	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
시판 약물 수	0
임상 약물 수	2
최고 연구 개발 단계	Phase 2 Clinical

Gremlin 제품 목록

속성
Protein (2)
제품 라이브러리
온라인 (2)
종
Human (2)
태그
His Tag (1)Fc Tag (1)
마커
Unconjugated (2)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
GR1-H5254	Human	HEK293	Human Gremlin / GREM1 Protein, Fc Tag
GR1-H52H3	Human	HEK293	Human Gremlin / GREM1 Protein, His Tag

총 수량2

Gremlin분자 배경

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Gremlin분자 별명

GREM1,CKTSF1B1,DAND2,DRM,PIG2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
TST-003	TST-003	Phase 2 Clinical	Suzhou Transcenta Therapeutics Co Ltd	Colorectal Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	상세
Ginisortamab	UCB-6114	Phase 2 Clinical	Ucb Biopharma Srl	Solid tumours	상세