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GPT

GPT Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
GPT-H51H3	Human	E. coli	Human GPT (1-496) protein, His Tag

Total: 1

GPT Background

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Naproxen/Caffeine	BAY-2880376	Phase 3 Clinical	Bayer AG	Pain, Postoperative	Details
Caffeinol		Phase 3 Clinical	Cardium Therapeutics	Alcoholic Intoxication; Alcoholism; Disruptive, Impulse Control, and Conduct Disorders; Carcinoma, Non-Small-Cell Lung	Details
Imaradenant	AZD-4635; HTL-1071	Phase 2 Clinical	Nxera Pharma UK Ltd	Solid tumours; Prostatic Neoplasms, Castration-Resistant	Details
Ciforadenant	CPI-444; V-81444	Phase 2 Clinical	Vernalis (R&D) Ltd	Carcinoma, Renal Cell; Neoplasms; Attention Deficit Disorder with Hyperactivity; Multiple Myeloma; Parkinson Disease; Carcinoma, Non-Small-Cell Lung	Details
Etrumadenant	AB-928; GS-0928	Phase 2 Clinical	Arcus Biosciences Inc	Prostatic Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Mouth Neoplasms; Pharyngeal Neoplasms; Carcinoma, Squamous Cell; Endometrial Neoplasms; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Colorectal Neoplasms; Oropharyngeal Neoplasms; Breast Neoplasms; Head and Neck Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Hypopharyngeal Neoplasms; Carcinoma, Transitional Cell; Esophageal Neoplasms; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Ovarian Neoplasms	Details
KW-6356	KW-6356	Phase 2 Clinical	Kyowa Hakko Kirin Co Ltd	Parkinson Disease; Hepatic Insufficiency	Details
PORT-8	PORT-8; TT-53	Phase 2 Clinical	Tarus Therapeutics Inc	Solid tumours	Details
PORT-6	PORT-6; TT-10	Phase 2 Clinical	Impetis Biosciences Ltd	Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Non-Small-Cell Lung	Details
VG081821AC	VG-081821AC; VG081821AC	Phase 2 Clinical	Zhejiang Vimgreen Pharmaceuticals Ltd	Parkinson Disease	Details
ILB-2109	WTS-001; ILB-2109	Phase 2 Clinical	Hangzhou Wutong Tree Pharmaceutical Co Ltd	Solid tumours; Neoplasms	Details
PBF-999	PBF-999	Phase 1 Clinical	Palobiofarma Sl	Neoplasms; Huntington Disease	Details
SHR-5126	SHR-5126	Phase 1 Clinical		Neoplasms	Details
Taminadenant	NIR-178; PBF-509	Phase 1 Clinical	Palobiofarma Sl	Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Carcinoma, Renal Cell; Carcinoma; Triple Negative Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Parkinson Disease; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma	Details
ST-4206	ST-4206	Phase 1 Clinical	Alfasigma Spa	Parkinson Disease	Details
JNJ-86974680	JNJ-86974680	Phase 1 Clinical	Johnson & Johnson Enterprise Innovation Inc	Carcinoma, Non-Small-Cell Lung	Details
YZJ-5053	YZJ5053; YZJ-5053	Phase 1 Clinical	Shanghai Haiyan Pharmaceutical Technology Co Ltd	Solid tumours; Neoplasm Metastasis	Details
CT-1500	CT-1500	Phase 1 Clinical	Circadian Technologies Ltd		Details
DZD-2269		Phase 1 Clinical	Dizal Pharmaceutical Co Ltd	Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms	Details
INCB-106385	INCB-106385	Phase 1 Clinical	Incyte Corp	Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular	Details
CS-3005	CS-3005	Phase 1 Clinical	Cstone Pharmaceuticals (Suzhou) Co Ltd	Solid tumours	Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine/Mannitol/Sodium Chloride					Details
Sodium Citrate/Citric Acid/Dextrose					Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine					Details
Aspirin/Acetaminophen/Caffeine/Thiamine					Details
Propranolol hydrochloride/Caffeine/Phenytoin Sodium					Details
Ethenzamide/Caffeine/Chlorzoxazone					Details
Salicylamide/Acetaminophen/Caffeine					Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Regadenoson Hydrate	CVT-3146	Approved	Astellas Pharma Inc	Lexiscan, Rapiscan	United States	Contrast agents	Astellas Pharma Inc	2008-04-10	Myocardial Ischemia; Rejection of lung transplantation; Cardiovascular contrast agents; Pneumonia; Glioblastoma; Coronary Artery Disease; Retinal Artery Occlusion; Heart Diseases; Coronavirus Disease 2019 (COVID-19); Oligodendroglioma; Contrast agents; Astrocytoma; Cardiovascular Diseases; Glioma; Diagnostic agents; Anemia, Sickle Cell	Details
Caffeine/Ergotamine Tartrate		Approved	Novartis Pharma Ag	Cafergot	Mainland China	Migraine Disorders	Tianjin Medical University Pharmaceutical Factory	1948-11-26	Migraine Disorders	Details
Oxtriphylline		Approved		Theocolin	Canada		null		Asthma	Details
Caffeine/Metamizole Sodium/Dihydroergotamine Mesylate		Approved		Cefaliv					Migraine Disorders	Details
Adenine		Approved		Leucon	Japan	Leukopenia	Ohara Pharmaceutical Co Ltd		Leukemia; Leukopenia	Details
Istradefylline	KW-6002	Approved	Kyowa Hakko Kirin Co Ltd	Nourianz, Nouriast	Japan	Parkinson Disease	Kyowa Hakko Kirin Co Ltd	2013-03-25	Substance-Related Disorders; Restless Legs Syndrome; Sleep Wake Disorders; Parkinson Disease; Hepatic Insufficiency; Movement Disorders; Cognition Disorders; Amyotrophic Lateral Sclerosis	Details
Acetaminophen/Methylephedrine Hydrochloride/Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Caffeine/Sulfogaiacol		Approved			Mainland China	Common Cold	Zhejiang Apeloa Kangyu Pharmaceutical Co Ltd		Common Cold	Details
Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Sodium Citrate/Ammonium Chloride/Caffeine		Approved		尔可芬					Cough	Details
Acetaminophen/Caffeine/Codeine Phosphate/Diphenhydramine Hydrochloride		Approved		斯力帮					Headache	Details
Ferric Ammonium Citrate/Vitamin B1/Sodium glycerophosphate/Caffeine		Approved							Ischemia	Details
Norethidranum Dipropionas/Caffeine/Vitamin B6		Approved			Mainland China	Contraception	Huazhong Pharmaceutical Co Ltd	1981-01-01	Contraception	Details
Acetaminophen/Propyphenazone/Caffeine		Approved		散利痛, 散列通					Common Cold	Details
Quinine Hydrochloride Hydrate/Caffeine		Approved							Malaria	Details
Dihydroergocryptine/Caffeine		Approved		洛斯宝, VASOBRAL					Diabetic Retinopathy; Diabetes Mellitus	Details
Aminophenazone/Phenacetin/Caffeine		Approved							Pain; Fever	Details
Aminophenazone/Caffeine/Calcium Glycerophosphate		Approved							Headache; Dysmenorrhea; Neuralgia	Details
Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved							Common Cold	Details
Aminophenazone/Caffeine/Chlorphenamine Maleate		Approved							Headache; Common Cold; Neuralgia	Details
Aspirin/Caffeine/Codeine Phosphate		Approved		柯克					Pain	Details
Acetaminophen/Pseudoephedrine Hydrochloride/Caffeine		Approved							Common Cold	Details
Aspirin/Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved							Common Cold	Details
Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric Acid		Approved							Common Cold	Details
Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine Maleate		Approved							Common Cold	Details
Aminophenazone/Phenacetin/Caffeine/Phenobarbital		Approved							Migraine Disorders	Details
Acetaminophen/Chlorphenamine Maleate/Caffeine/Guaifenesin		Approved							Common Cold	Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Artificial Bezoar		Approved							Common Cold	Details
Acetaminophen/Salicylamide/Pseudoephedrine Hydrochloride/Caffeine/Triprolidine Hydrochloride Hydrate		Approved		联邦菲迪乐					Common Cold	Details
Sodium Benzoate/Caffeine		Approved							Central Nervous System Diseases	Details
Aminophenazone/Caffeine		Approved							Fever	Details
Antipyrine/Caffeine		Approved							Common Cold	Details
Aspirin/Caffeine		Approved							Common Cold	Details
Antipyrine/Caffeine/Citric Acid		Approved		米格来宁	Mainland China	Sedation	Xi'An Disai Biological Pharmaceutical Co Ltd, Heilongjiang Hasing Pharmaceutical Group Co Ltd, Huadong Medicine (Xi'An) Bodyguard Pharmaceutical Co Ltd, Mudanjiang Lingtai Medicdment Co Ltd	1982-01-01	Sedation	Details
Aminophenazone/Acetaminophen/Caffeine/Chlorphenamine Maleate		Approved		克感敏, 扑感敏, 朴感敏					Common Cold	Details
Acetaminophen/Caffeine/Ephedrine Hydrochloride/Diphenhydramine Hydrochloride		Approved							Influenza, Human	Details
Acetaminophen/Caffeine/Chlorphenamine Maleate/Artificial Bezoar		Approved							Common Cold	Details
Aspirin/Phenacetin/Caffeine		Approved							Headache; Dysmenorrhea; Toothache; Neuralgia; Fever; Arthralgia	Details
Aspirin/Caffeine/Acetaminophen		Approved			United States	Migraine Disorders	Haleon PLC		Migraine Disorders; Anesthesia	Details
Acetaminophen/Butalbital/Caffeine		Approved							Headache	Details
Acetaminophen/Caffeine		Approved	Zentiva As		Mainland China	Pain	Sino--American Shanghai Squibb Pharmaceutical Ltd		Pain	Details
Sodium glycerophosphate/Caffeine/Vitamin B/Phosphoric Acid/Niacin		Approved								Details
Acetaminophen/Caffeine/Phenylephrine Hydrochloride/Chlorphenamine Maleate/Vitamin B		Approved								Details
Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine		Approved			Mainland China	Common Cold	Hainan Sanfengyou Pharmaceutical Co Ltd	2006-05-16	Common Cold	Details
Brompheniramine Maleate/Bromhexine Hydrochloride/Caffeine/Acetaminophen/Phenylephrine Hydrochloride		Approved							Common Cold	Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Chlorphenamine Maleate/Artificial Bezoar		Approved		复方氨酚烷胺	Mainland China	Common Cold	null	1984-01-01	Common Cold	Details
Caffeine		Approved							Fatigue; Mental Fatigue; Memory Disorders; Cocaine-Related Disorders; Sexual Dysfunction, Physiological; Parkinson Disease; Cognitive Dysfunction; Diabetes Complications; Diabetic Nephropathies; Postoperative Cognitive Complications; Diabetes Mellitus, Type 1; Delirium; Apnea; Disorders of Excessive Somnolence; Intermittent Claudication; Spinal Cord Injuries; Fetal Membranes, Premature Rupture; Consciousness; Sleepiness	Details