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GM-CSF R alpha

GM-CSF R alpha Overview

English Name	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha	Approved Drugs	0
Drugs in Clinical Trials	4	Target Synonym	GM-CSF-R-alpha，GMCSFR-alpha，GMR-alpha，CD116，Colony Stimulating Factor 2 Receptor Subunit Alpha，Colony Stimulating Factor 2 Receptor， Alpha， Low-Affinity (Granulocyte-Macrophage)，CSF2R，CSF2RAX，CSF2RAY，CSF2RX，CSF2RY，GM-CSF Receptor Alpha Subunit，GMCSFR，GMR，Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain，SMDP4，Colony Stimulating Factor 2 Receptor Alpha Subunit，CDw116，CD116 Antigen，Alpha-GM-CSF Receptor，AlphaGMR
Highest Development Stage	Phase 3 Clinical

English Name	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Target Synonym	GM-CSF-R-alpha，GMCSFR-alpha，GMR-alpha，CD116，Colony Stimulating Factor 2 Receptor Subunit Alpha，Colony Stimulating Factor 2 Receptor， Alpha， Low-Affinity (Granulocyte-Macrophage)，CSF2R，CSF2RAX，CSF2RAY，CSF2RX，CSF2RY，GM-CSF Receptor Alpha Subunit，GMCSFR，GMR，Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain，SMDP4，Colony Stimulating Factor 2 Receptor Alpha Subunit，CDw116，CD116 Antigen，Alpha-GM-CSF Receptor，AlphaGMR
Approved Drugs	0
Drugs in Clinical Trials	4
Highest Development Stage	Phase 3 Clinical

GM-CSF R alpha Product List

Product Category
Protein (3)
Product Status
Launched (3)
Species
Human (2)Mouse (1)
Tag
His Tag (2)Fc Tag (1)
Conjugate
Unconjugated (3)

Cat. No.	Species	Host	Product Description
HOT GRA-H52H7	Human	HEK293	Human GM-CSF R alpha Protein, His Tag (SPR verified)
GRA-H5255	Human	HEK293	Human GM-CSF R alpha Protein, Fc Tag
GMA-M52H3	Mouse	HEK293	Mouse GM-CSF R alpha Protein, His Tag

Total: 3

GM-CSF R alpha Background

GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.

GM-CSF R alpha Synonyms

GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Mavrilimumab	CAM-3001; KPL-301; GM-CSFR; CAM3001	Phase 3 Clinical	Csl Ltd	Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Giant Cell Arteritis; Pneumonia	Details
Anti-GMR CAR T-cell Therapy		Phase 2 Clinical	Kyoto Prefectural University Of Medicine, Shinshu University School of Medicine	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Juvenile	Details
CSF2RA gene-corrected macrophages(University of South Florida)		Phase 2 Clinical	Russian Academy Of Medical Sciences	Pulmonary Alveolar Proteinosis	Details
STSA-1005	STSA-1005; STSA1005	Phase 1 Clinical	Staidson(Beijing) Biopharmaceuticals Co Ltd	Coronavirus Disease 2019 (COVID-19)	Details