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GITR Ligand

GITR Ligand Overview

English Name	Tumor necrosis factor ligand superfamily member 18	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	AITRL，GITRL，TL6，UNQ149，PRO175，Glucocorticoid-induced TNF-related ligand，hGITRL，Activation-inducible TNF-related ligand
Highest Development Stage	Preclinical

English Name	Tumor necrosis factor ligand superfamily member 18
Target Synonym	AITRL，GITRL，TL6，UNQ149，PRO175，Glucocorticoid-induced TNF-related ligand，hGITRL，Activation-inducible TNF-related ligand
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

GITR Ligand Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (5)Mouse (1)
Tag
Fc Tag (3)Avi Tag & Fc Tag (1)His Tag (2)
Conjugate
Unconjugated (5)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT GIL-H5249	Human	HEK293	Human GITR Ligand / TNFSF18 Protein, His Tag
HOT GIL-H524a	Human	HEK293	Human GITR Ligand / TNFSF18 Protein, His Tag, active trimer (MALS verified)
HOT GIL-H5263	Human	HEK293	Human GITR Ligand / TNFSF18 Protein, Fc Tag, active trimer (MALS verified)
GIL-H526a	Human	HEK293	Human GITR Ligand / TNFSF18 Protein, Fc Tag
GIL-H82F8	Human	HEK293	Biotinylated Human GITR Ligand / TNFSF18 Protein, Avitag™,Fc Tag
GIL-M526x	Mouse	HEK293	Mouse GITR Ligand / TNFSF18 Protein, Fc Tag

Total: 6

GITR Ligand Background

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.