언어 선택

GDNF

GDNF 분자 정보

영어 이름	Glial cell line-derived neurotrophic factors	시판 약물 수	0
임상 약물 수	5	표적 별명	Glial Cell Line-Derived Neurotrophic Factors
최고 연구 개발 단계	NDA/BLA

영어 이름	Glial cell line-derived neurotrophic factors
표적 별명	Glial Cell Line-Derived Neurotrophic Factors
시판 약물 수	0
임상 약물 수	5
최고 연구 개발 단계	NDA/BLA

GDNF 제품 목록

속성
Protein (5)Kits (1)
제품 라이브러리
온라인 (6)
종
Human (5)Mouse (1)
태그
Tag Free (4)His Tag (1)- (1)
마커
Unconjugated (5)- (1)

제품 번호	종	발현 시스템	제품 설명
GDF-H5118	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), premium grade
GDF-H5119	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade
GDF-H5219	Human	HEK293	Human GDNF / ATF / hGDNF Protein, premium grade
GMP-GDFH17	Human	E. coli	GMP Human GDNF Protein (E. coli)
RES-A117	Human	-	resDetect™ GDNF ELISA kit (Residue Testing)
GDF-M5245	Mouse	HEK293	Mouse GDNF / ATF Protein, His Tag, low endotoxin (MALS verified)

총 수량6

GDNF분자 배경

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

GDNF분자 별명

GDNF,ATF

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
AB-1005	AMT-140; AB-1005; AAV2-GDNF; AAV2-GDNF-MSA; AAV2-GDNF-PD	Phase 2 Clinical	Uc San Francisco	Multiple System Atrophy; Parkinson Disease	상세
NRO-1	NRO-1; SI-01	Phase 2 Clinical	Senju Pharmaceutical Co Ltd	Xerophthalmia	상세
Ifezuntirgene inilparvovec	AAV5-miSNP15; AMT-130; AAV5-miHtt12; AAV5-miSNP7	Phase 2 Clinical	Amsterdam Molecular Therapeutics, Uniqure	Huntington Disease	상세
AAV2-GDNF gene therapy (NINDS)		Phase 1 Clinical	National Institute Of Neurological Disorders And Stroke	Parkinson Disease	상세
RGL-193	RGL-193	Phase 1 Clinical	Shanghai Regenelead Therapies Co Ltd	Parkinson Disease	상세

제품 리뷰

P***i2025-05-13
0사람들이 좋아합니다
Human GDNF / ATF / hGDNF Protein, premium grade
Acro Biosystems' GDNF recombinant protein has proven to be a reliable and high-quality reagent for research focused on neuronal development and maturation. In my study involving cortical projection neuron cultures, GDNF consistently supported neuronal survival, neurite outgrowth, and the expression of maturation markers. Its batch-to-batch consistency and biological activity have made it an essential component in our differentiation protocols. I highly recommend this product to laboratories engaged in both fundamental neuroscience research and translational studies aiming to model neurodegenerative diseases or explore neuroprotective strategies.