언어 선택

GDF-11

제품 문의

GDF-11분자 배경

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Recombinant humanized anti-IL-6R antibody (Hisun Pharma)	HS-628	Phase 3 Clinical	Zhejiang Hisun Pharmaceutical Co Ltd	Arthritis, Rheumatoid; Arthritis	상세
VDJ-001		Phase 3 Clinical	Beijing Vdjbio Co Ltd	Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD)	상세
Tocilizumab biosimilar (AryoGen Pharmed)		Phase 3 Clinical	Aryogen Biopharma	Arthritis, Rheumatoid	상세
CMAB806	CMAB-806	Phase 3 Clinical	Taizhou Maibo Taike Biotechnology Co Ltd	Arthritis, Rheumatoid; Arthritis	상세
Levilimab	BCD-089	Phase 3 Clinical	Biocad	Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19)	상세
Olamkicept	FE-999301; CR-5/18; TJ-301; FE-301	Phase 2 Clinical	Conaris Research Institute	Gastrointestinal Diseases; Colitis, Ulcerative	상세
Atexakin alfa	SON-080; r-IL-6	Phase 2 Clinical	Weizmann Institute Of Science	Peripheral Nervous System Diseases; Diabetic Neuropathies	상세
Tocilizumab Biosimilar (qyuns)	QX-003-S	Phase 1 Clinical	Qyuns Therapeutics Co Ltd	Arthritis, Rheumatoid	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Tocilizumab	rhPM-1; RO-48775533; RG-1569; MRA; HPM-1; MRA-SC; R-1569	Approved	Chugai Pharmaceutical Co Ltd	Actemra, RoActemra, 雅美罗, Actemra/RoActemra, Acterma	Japan	Arthritis, Juvenile; Arthritis, Rheumatoid; Giant Cell Arteritis; Takayasu Arteritis; Cytokine Release Syndrome; Multicentric Castleman's Disease (MCD)	null	2005-04-11	Lymphoma; Graves Ophthalmopathy; Ascites; Takayasu Arteritis; Pancreatitis, Chronic; Coronavirus Infections; Pulmonary Arterial Hypertension; Coronary Disease; Lupus Erythematosus, Systemic; Breast Neoplasms; systemic sclerosis-associated interstitial lung disease; Multicentric Castleman's Disease (MCD); Fever; Uveitis, Posterior; Stroke; Pulmonary Disease, Chronic Obstructive; Osteoarthritis; Uveitis; Rejection in heart transplantation; Inflammation; Pleural Effusion, Malignant; Panuveitis; Diabetes Mellitus; Behcet Syndrome; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Carcinoma, Hepatocellular; Non-ST Elevated Myocardial Infarction; Myocardial Infarction; Hematologic Neoplasms; Solid tumours; Cytokine Release Syndrome; Motor Neuron Disease; HIV Infections; Diabetes Mellitus, Type 1; Acute Chest Syndrome; Craniopharyngioma; Polymyositis; Giant Cell Arteritis; Schnitzler Syndrome; Depressive Disorder, Major; Polyarticular Juvenile Idiopathic Arthritis; Non-radiographic axial spondyloarthritis; Uveitis	상세
Tocilizumab biosimilar (Bio-Thera Solutions)	BAT-1806; BIIB-800	Approved	Bio-Thera Solutions Ltd	施瑞立, TOFIDENCE	Mainland China	Arthritis, Rheumatoid; Arthritis, Juvenile; Cytokine Release Syndrome	Bio-Thera Solutions Ltd	2023-01-16	Cytokine Release Syndrome; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Arthritis, Juvenile	상세
Sarilumab	SAR-153191; REGN-88	Approved	Sanofi	Kevzara	United States	Arthritis, Rheumatoid	Sanofi-Synthelabo	2017-05-22	Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mastocytosis, Systemic; Arthritis, Juvenile; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Uveitis	상세
Tocilizumab biosimilar (Livzon Group)	LZM-008	Approved	Livzon Pharmaceutical Group Inc	安维泰	Mainland China	Arthritis, Rheumatoid	Livzon Mabpharm Inc	2023-01-18	Arthritis, Rheumatoid	상세
Tocilizumab biosimilar (Fresenius kabi)	MSB-11456	Approved	Merck Serono	Tyenne®	EU	Cytokine Release Syndrome; Arthritis, Rheumatoid; Giant Cell Arteritis; Coronavirus Disease 2019 (COVID-19)	Fresenius Kabi Deutschland Gmbh	2023-09-15	Cytokine Release Syndrome; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19)	상세