언어 선택

GAD2

GAD2 분자 정보

영어 이름	Glutamate decarboxylase 2	시판 약물 수	0
임상 약물 수	1	표적 별명	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
최고 연구 개발 단계	Pending

영어 이름	Glutamate decarboxylase 2
표적 별명	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Pending

GAD2 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
GA2-H55H3	Human	InsectCells	Human GAD2 / GAD65 Protein, His Tag

총 수량1

GAD2분자 배경

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.