Select Language

Frizzled-7

Frizzled-7 Overview

English Name	Frizzled-7	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Highest Development Stage	Phase 1 Clinical

English Name	Frizzled-7
Target Synonym	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

Frizzled-7 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
Fc Tag (1)His Tag (1)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FZ7-H5258	Human	HEK293	Human Frizzled-7 / FZD7 Protein, Fc Tag
FZ7-H52H9	Human	HEK293	Human Frizzled-7 / FZD7 Protein, His Tag

Total: 2

Frizzled-7 Background

Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

Frizzled-7 Synonyms

FZD7,Frizzled-7,FzE3,Fz-7,hFz7

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	Details