Select Language

Frizzled-2

Frizzled-2 Overview

English Name	Frizzled-2	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2
Highest Development Stage	Phase 1 Clinical

English Name	Frizzled-2
Target Synonym	Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

Frizzled-2 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
Fc Tag (2)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FZ2-H5251	Human	HEK293	Human Frizzled-2 / FZD2 Protein, Fc Tag
FZ2-H5255	Human	HEK293	Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag

Total: 2

Frizzled-2 Background

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Frizzled-2 Synonyms

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	Details