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Flt-3

Flt-3

Flt-3 분자 정보

Molecule Name
Tyrosine-protein kinase receptor FLT3
분자 별명
Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
Drug Development Progress
임상 약물 수60
시판 약물 수14
최고 연구 개발 단계Approved
표적 별명
EC:2.7.10.1，CD135 Antigen，CD135，STK1，Growth Factor Receptor Tyrosine Kinase Type III，Fms-Related Tyrosine Kinase 3，Fetal Liver Kinase 2，Fetal Liver Kinase-2，EC 2.7.10.1，fms-Like Tyrosine Kinase 3，Receptor-type tyrosine-protein kinase FLT3，FLT3，FLT-3，FLK2，STK-1，FL cytokine receptor，Fms Related Tyrosine Kinase 3，Stem Cell Tyrosine Kinase 1，FLK-2，Fms Related Receptor Tyrosine Kinase 3，EC 2.7.10
분자 배경
Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Flt-3 제품 목록

Species
  • Human（4）
  • Cynomolgus（1）
  • Mouse（1）
Tag
  • His Tag（3）
  • Fc Tag（2）
  • His Tag & Avi Tag（1）
Host
  • HEK293（6）
Conjugate
  • Unconjugated（4）
  • Biotin-labeled（1）
  • FITC Labeled（1）
Grade
  • RUO（6）
Low Endotoxin
  • No（6）
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
Flt-3
HOT
FL3-C52H5
Cynomolgus Flt-3 / Flk-2 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$535.00

100ug
Flt-3
HOTAvitag
FL3-H82E3
Biotinylated Human Flt-3 / Flk-2 Protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Flt-3
HOT
FL3-H52H6
Human Flt-3 / Flk-2 Protein, His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$370.00

100ug
Flt-3
FL3-H5258
Human Flt-3 / Flk-2 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$310.00

100ug
Flt-3
FL3-HF255
FITC-Labeled Human Flt-3 / Flk-2 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISA

$330.00

25ug
Flt-3
FL3-M52H6
Mouse Flt-3 / Flk-2 Protein, His Tag
Mouse
HEK293
SDS-PAGE
ELISASPR

$360.00

100ug
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임상 약물 정보

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시판 약물 정보

영어 이름연구 코드연구 개발 단계회사가장 빠른 브랜드 이름가장 빠른 승인 국가가장 빠른 적응증가장 빠른 승인 회사가장 빠른 승인 날짜적응증임상 시험
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Hepatic Insufficiency; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours
상세
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상세
Nintedanib EsylateBIBF-1120ApprovedC.H. Boehringer Sohn Ag & Co. KgOfev, VargatefUnited StatesIdiopathic Pulmonary FibrosisBoehringer Ingelheim International Gmbh2014-10-15
Adenocarcinoma, Clear Cell; Appendiceal Neoplasms; Asbestosis; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Endometrial Stromal Tumors; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Mesothelioma; Multiple Myeloma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Fibrosis; Radiation Pneumonitis; Rejection of lung transplantation; Sarcoma; Scleroderma, Systemic; Silicosis; Small Cell Lung Carcinoma; Solid tumours; systemic sclerosis-associated interstitial lung disease; Telangiectasia, Hereditary Hemorrhagic; Uterine Neoplasms
상세
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Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Choroidal Neovascularization; Diabetic macular oedema; Diabetic Retinopathy; Eye Diseases; Gastroesophageal Junction Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Macular Degeneration; Melanoma; Neoplasms; Pancreatic Neoplasms; Retinal Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Wet Macular Degeneration
상세
Gilteritinib FumarateASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code)ApprovedAstellas Pharma IncXospataJapanLeukemia, Myeloid, AcuteAstellas Pharma Inc2018-09-21
Carcinoma, Non-Small-Cell Lung; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Renal Insufficiency; Solid tumours
상세
Pacritinib CitrateONX-0803; SB-1518ApprovedS*BIO Pte LtdVONJO, Epjevy, ENPAXIQUnited StatesPrimary MyelofibrosisSobi2022-02-28
Bone Marrow Diseases; Carcinoma, Non-Small-Cell Lung; Castleman Disease; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Graft vs Host Disease; Hematologic Diseases; Hepatic Insufficiency; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Lymphoma; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Myelodysplastic Syndromes; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Sarcoma, Kaposi; Thrombocythemia, Essential; Thrombocytopenia; VEXAS Syndome; Waldenstrom Macroglobulinemia
상세
FedratinibTG-101348; SAR-302503ApprovedSanofiInrebicUnited StatesPrimary MyelofibrosisBristol-Myers Squibb Company2019-08-16
Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Neutrophilic, Chronic; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Renal Insufficiency; Splenomegaly; Thrombocythemia, Essential
상세
Ponatinib HydrochlorideAP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534ApprovedAriad英可欣, IclusigUnited StatesLeukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-LymphomaAriad Pharmaceuticals Inc2012-12-14
Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Non-Small-Cell Lung; Common Bile Duct Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Chronic; Lymphoma; Medullary thyroid cancer (MTC); Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms
상세
Sunitinib MalatePNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate saltApprovedPfizer IncSutent, 索坦United StatesGastrointestinal Stromal Tumors; Carcinoma, Renal CellCppi Cv2006-01-26
Abdominal Neoplasms; Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenocortical Carcinoma; AIDS-Related Complex; Amyloidosis; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Barrett Esophagus; Brain metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Adenosquamous; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Choriocarcinoma; Chronic eosinophilic leukemia (CEL); Cognition Disorders; Colorectal Neoplasms; Diabetic macular oedema; Endodermal Sinus Tumor; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Fibrosarcoma; Gastrointestinal Stromal Tumors; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangi
상세
PexidartinibPLX-3397ApprovedDaiichi Sankyo Co LtdTuralioUnited StatesGiant Cell Tumor of Tendon SheathDaiichi Sankyo Inc2019-08-02
Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumor of Tendon Sheath; Giant Cell Tumors; Glioblastoma; Hodgkin Disease; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Melanoma; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Neurofibroma, Plexiform; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular
상세
Cabozantinib S-malateXL-184; BMS-907351; RO7047650; RO-7047650ApprovedExelixis IncCometriq, CabometyxUnited StatesThyroid Neoplasms; Carcinoma, NeuroendocrineExelixis Inc2012-11-29
Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin
상세
Sorafenib TosylateNSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085ApprovedOnyx Pharmaceuticals IncNexavar, 多吉美United StatesCarcinoma, Renal CellBayer Healthcare Pharmaceuticals Inc2005-12-01
Abdominal Neoplasms; Adenocarcinoma; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Colonic Neoplasms; Esophageal Neoplasms; Facial Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gallbladder Neoplasms; Gastrinoma; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Glucagonoma; Head and Neck Neoplasms; Heart Arrest; Hemangiosarcoma; Hepatopulmonary Syndrome; Histiocytoma, Malignant Fibrous; Hypertension, Portal; Hypopharyngeal Neoplasms; Insulinoma; Kidney Diseases; Kidney Neoplasms; Laryngeal Diseases; Laryngeal Neoplasms; Leiomyosarcoma; Leukemia, Basophilic, Acute; Leukemia, Eosin
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Famitinib MalateSHR-1020ApprovedJiangsu Hengrui Medicine Co Ltd艾比特Mainland ChinaUterine Cervical NeoplasmsJiangsu Hengrui Medicine Co Ltd2025-05-27
Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms
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MidostaurinPKC-412; PKC-412A; CGP-41231; CGP-41251ApprovedNovartis Pharma AgRydaptUnited StatesHematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-CellNovartis Pharmaceuticals Corp2017-04-28
Hematologic Neoplasms; Hepatic Insufficiency; Leukemia; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Mastocytosis; Mastocytosis, Systemic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
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