언어 선택

Flt-3

Flt-3 분자 정보

영어 이름	Tyrosine-protein kinase receptor FLT3	시판 약물 수	14
임상 약물 수	60	표적 별명	EC:2.7.10.1，CD135 Antigen，CD135，STK1，Growth Factor Receptor Tyrosine Kinase Type III，Fms-Related Tyrosine Kinase 3，Fetal Liver Kinase 2，Fetal Liver Kinase-2，EC 2.7.10.1，fms-Like Tyrosine Kinase 3，Receptor-type tyrosine-protein kinase FLT3，FLT3，FLT-3，FLK2，STK-1，FL cytokine receptor，Fms Related Tyrosine Kinase 3，Stem Cell Tyrosine Kinase 1，FLK-2，Fms Related Receptor Tyrosine Kinase 3，EC 2.7.10
최고 연구 개발 단계	Approved

영어 이름	Tyrosine-protein kinase receptor FLT3
표적 별명	EC:2.7.10.1，CD135 Antigen，CD135，STK1，Growth Factor Receptor Tyrosine Kinase Type III，Fms-Related Tyrosine Kinase 3，Fetal Liver Kinase 2，Fetal Liver Kinase-2，EC 2.7.10.1，fms-Like Tyrosine Kinase 3，Receptor-type tyrosine-protein kinase FLT3，FLT3，FLT-3，FLK2，STK-1，FL cytokine receptor，Fms Related Tyrosine Kinase 3，Stem Cell Tyrosine Kinase 1，FLK-2，Fms Related Receptor Tyrosine Kinase 3，EC 2.7.10
시판 약물 수	14
임상 약물 수	60
최고 연구 개발 단계	Approved

Flt-3 제품 목록

속성
Protein (6)
제품 라이브러리
온라인 (6)
종
Human (4)Mouse (1)Cynomolgus (1)
태그
Fc Tag (2)His Tag (3)His Tag & Avi Tag (1)
마커
Unconjugated (4)Biotin-labeled (1)FITC Labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT FL3-H52H6	Human	HEK293	Human Flt-3 / Flk-2 Protein, His Tag (MALS verified)
HOT FL3-H82E3	Human	HEK293	Biotinylated Human Flt-3 / Flk-2 Protein, His,Avitag™ (MALS verified)
HOT FL3-C52H5	Cynomolgus	HEK293	Cynomolgus Flt-3 / Flk-2 Protein, His Tag (MALS verified)
FL3-H5258	Human	HEK293	Human Flt-3 / Flk-2 Protein, Fc Tag (MALS verified)
FL3-HF255	Human	HEK293	FITC-Labeled Human Flt-3 / Flk-2 Protein, Fc Tag
FL3-M52H6	Mouse	HEK293	Mouse Flt-3 / Flk-2 Protein, His Tag

총 수량6

Flt-3분자 배경

Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Flt-3분자 별명

Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
XY-0206	XY-0206	Phase 3 Clinical	Nanjing University Of Chinese Medicine	Leukemia, Myeloid, Acute; Solid tumours	상세
Clifutinib Besylate	HEC-73543	Phase 3 Clinical	Guangdong Dongyangguang Pharmaceutical Co Ltd	Leukemia, Myeloid, Acute	상세
KC1036	KC1036; KC-1036	Phase 3 Clinical	Beijing Konruns Pharmaceutical Co Ltd	Adenocarcinoma; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Hematologic Neoplasms; Neoplasm Metastasis; Sarcoma, Ewing; Solid tumours; Thymus Neoplasms	상세
Ruserontinib	SKLB-1028	Phase 3 Clinical	CSPC Pharmaceutical Group Ltd, Sichuan University	Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Solid tumours	상세
Lestaurtinib	SPM-924; A-154475.0; KT-5555; SP-924; CEP-701	Phase 3 Clinical	Kyowa Hakko Kirin Co Ltd	Bone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential	상세
Crenolanib Besylate	CP-868596-26; IND-112201; CP-868596; ARO-002; ARO-002-26; CP-868; 596-26; CP-868; 596	Phase 3 Clinical	Pfizer Inc	Gastrointestinal Stromal Tumors; Glioma; Leukemia, Myeloid, Acute	상세
Flonoltinib maleate		Phase 3 Clinical	Chengdu Zenitar Biomedical Technology Co Ltd	Alopecia Areata; Filariasis; Graft vs Host Disease; Lymphohistiocytosis, Hemophagocytic; Myeloproliferative Disorders; Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential	상세
HYML-122	HYML-122; CHMFL-FLT3-122	Phase 2 Clinical	Hefei Academy Of Physical Sciences, Chinese Academy Of Sciences, Hefei Cosource Pharmaceuticals	Leukemia, Myeloid, Acute	상세
Ningetinib Tosylate	CT-053-PTSA; CT-053	Phase 2 Clinical	Hec Pharm Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Intestinal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Solid tumours; Stomach Neoplasms	상세
MRX-2843	UNC-2371; UNC-2025; MRX-2843	Phase 2 Clinical	University Of North Carolina At Chapel Hill	Carcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Neoplastic Processes; Pathologic Processes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	상세
Emavusertib	AU-4948; CA-4948	Phase 2 Clinical	Aurigene	Anemia; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Stomach Neoplasms; Urologic Neoplasms	상세
Zotiraciclib	SB-1317; TG-02	Phase 2 Clinical	Syncore Biotechnology Co Ltd	Astrocytoma; Brain Neoplasms; Carcinoma, Hepatocellular; Glioblastoma; Glioma; Gliosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms	상세
Nefextinib hemifumarate	MAX-40279-001; Max-40279; MAX-40279-01; MAX-4; MAX-5; Max-6	Phase 2 Clinical	MaxiNovel Pharmaceuticals Co Ltd	Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Idiopathic Pulmonary Fibrosis; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasm Metastasis; Solid tumours; Stomach Neoplasms	상세
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	상세
CDX-301 (Amgen)	CDX-301	Phase 2 Clinical	Amgen Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Melanoma; Metastatic breast cancer; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck; Uveal melanoma	상세
Narazaciclib	HX-301; ON-123300	Phase 2 Clinical	Temple University	Breast Neoplasms; Endometrial Neoplasms; Glioblastoma; Glioma; Multiple Myeloma; Solid tumours	상세
Tuspetinib	HM-43239	Phase 2 Clinical	Hanmi Pharmaceutical Co Ltd	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes	상세
Flysyn	4G8-SDIEM	Phase 2 Clinical	Synimmune Gmbh	Leukemia, Myeloid, Acute	상세
GB-3226	BRM-1420; GB-3226	Phase 2 Clinical	Bridge Medicines Inc	Leukemia, Myeloid, Acute	상세
Inhaled Nintedanib – dry powder (Avalyn Pharma)	AP02; AP 02 DP; AP-02; AP02-DP	Phase 2 Clinical	Avalyn Pharma Inc	Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Respiratory Tract Diseases	상세
Sorafenib Tosylate/Comekibart	MG-D-1609	Phase 2 Clinical	Metagone Biotech Inc	Solid tumours	상세
Anti-FLT3 CAR-T Cell Therapy (PersonGen Biomedicine)	TAA05	Phase 2 Clinical	Persongen Biotherapeutics (Suzhou) Co Ltd	Leukemia, Myeloid, Acute	상세
Mobinitinib fumerate	EP-0042	Phase 2 Clinical	Ellipses Pharma	Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes	상세
LNK-01002	LNK01002; LNK-1000318	Phase 2 Clinical	Lynk Pharmaceutical (Hangzhou) Co Ltd	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential	상세
Hydroxychloroquine/Sorafenib		Phase 2 Clinical	Vg Life Sciences	Ovarian Neoplasms; Solid tumours	상세
Dapolsertib hydrochloride	SEL24/MEN1703; SEL24; SEL-24-B489; SEL-24; SEL-24-1; MEN-1703	Phase 2 Clinical	Ryvu Therapeutics Sa	Leukemia, Myeloid, Acute; Lymphoma, B-Cell	상세
FN-1501	FN-1501; LT-171-861	Phase 2 Clinical	China Pharmaceutical University	Carcinoma, Hepatocellular; Leukemia, Myeloid, Acute; Neoplasms; Solid tumours	상세
Mivavotinib	TAK-659; CB-659	Phase 1 Clinical	Takeda Pharmaceutical Co Ltd	Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	상세
Emirodatamab	AMG-427	Phase 1 Clinical	Amgen Inc	Leukemia, Myeloid, Acute	상세
E-6201	E-6201	Phase 1 Clinical	Eisai Co Ltd	Brain metastases; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Melanoma; Myelodysplastic Syndromes; Plaque psoriasis; Psoriasis; Solid tumours	상세
HEMO-CAR-T therapy(Hemogenyx)	HG-CT-1	Phase 1 Clinical	Hemogenyx Pharmaceuticals PLC	Leukemia, Myeloid, Acute	상세
SENTI-202	SENTI-202	Phase 1 Clinical	Senti Biosciences Inc	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
ETH-155008	ETH-155008	Phase 1 Clinical	Yunnan Shengke Pharmaceutical Co Ltd	Leukemia; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin	상세
CLN-049	CLN-049	Phase 1 Clinical	Eberhard-Karls Universitaet Tuebingen, German Cancer Research Center (Dkfz)	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
Nintedanib Esylate Inhalation Powder(Cspc)		Phase 1 Clinical	Cspc-Nbp Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	상세
DPH-001	DPH-001; DPH001	Phase 1 Clinical	Disruptive Pharma AB		상세
BDT-272	BDT272; BDT-272	Phase 1 Clinical	Biodol Therapeutics	Pain	상세
TLX-83	TLX83; TLX-83	Phase 1 Clinical	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Yantai New Drug Creation Shandong Laboratory, Zhejiang University, Zhongshan Institute for Drug Discovery	Leukemia, Myeloid, Acute	상세
QBH-196	QBH-196	Phase 1 Clinical	Shenyang Pharmaceutical University	Solid tumours; Stomach Neoplasms	상세
VX-A901	VX-A901	Phase 1 Clinical	Veraxa Biotech GmbH	Leukemia, Myeloid, Acute	상세
CI-135	HR014; CI-135	Phase 1 Clinical	Hrain Biotechnology Co Ltd	Hematologic Neoplasms; Leukemia, Myeloid, Acute	상세
MNKD-201	MNKD-201; MKND-201	Phase 1 Clinical	MannKind Corp	Idiopathic Pulmonary Fibrosis	상세
ETN-101	ETN101; ETN-101; MBP-11901	Phase 1 Clinical	Etnova Therapeutics Corp	Carcinoma, Hepatocellular; Liver Neoplasms	상세
Lomonitinib		Phase 1 Clinical	Eilean Therapeutics LLC		상세
KME-0584	KME-0584	Phase 1 Clinical	Cincinnati Children'S Hospital Medical Center, National Center For Advancing Translational Sciences	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
Lomonitinib	ZE46-0134; ZE-46-0134; ZE-460134	Phase 1 Clinical	Eilean Therapeutics LLC	Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute	상세
ETH-155036	ETH-155036; ETH155036	Phase 1 Clinical	Shengke Pharmaceutical (Jiangsu) Co Ltd	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
HPB-092	HPB-092	Phase 1 Clinical	Polymed Biopharmaceuticals Inc	Leukemia, Myeloid, Acute	상세
FF-10101	FF-10101; FF-10101-01; FF-10101 succinate	Phase 1 Clinical	Fujifilm Corp	Leukemia, Myeloid, Acute	상세
STI-8591	STI8591; STI-8591	Phase 1 Clinical	Zhejiang Acea Pharmaceutical Co Ltd	Leukemia, Myeloid, Acute	상세
CTS-2016	CTS-2016	Phase 1 Clinical	CytosinLab Therapeutics Co Ltd	Leukemia, Myeloid, Acute; Myelodysplastic Syndromes	상세
PLM-102	PLM-102; PLD-102	Phase 1 Clinical	Pelemed Co Ltd	Leukemia, Myeloid, Acute	상세
BMF-500	BMF-500	Phase 1 Clinical	Biomea Fusion Inc	Leukemia, Myeloid, Acute	상세
RG-6392	RG-6392	Phase 1 Clinical	F.Hoffmann-La Roche Inc	Neoplasms	상세
T-1301	T-1301; DBPR-216; BPR-1J481; BPR1J481	Phase 1 Clinical	Taivex Therapeutics Corp	Lymphoma; Solid tumours	상세
TT-00973	TT-00973	Phase 1 Clinical	TransThera Sciences (Nanjing) Inc	Solid tumours	상세
Lasmotinib	PHI-101-002; PHI-101; PHI-101-003	Phase 1 Clinical	Pharos iBio Co Ltd	Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Ovarian Neoplasms; Peritoneal Neoplasms	상세
Denfivontinib Hydrochloride	SKI-G-801; G-801; G-749 Hydrochloride	Phase 1 Clinical	Genosco	Leukemia, Myeloid, Acute; Solid tumours	상세
Luxeptinib	CG026806; CG-806; CG’806; CG-026806	Phase 1 Clinical	Crystalgenomics Inc	Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes	상세
Sorafenib tosylate (Bio-Synectics)	BS-104	Clinical	Bio-Synectics Inc		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Quizartinib	AC-010220; ASP-2689; AC-220	Approved	Ambit Biosciences Co	Vanflyta	Japan	Leukemia, Myeloid, Acute	Daiichi Sankyo Co Ltd	2019-06-18	Hepatic Insufficiency; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	상세
Brigatinib	AP-26113	Approved	Ariad Pharmaceuticals Inc	Alunbrig, ALUNBRIG	United States	Carcinoma, Non-Small-Cell Lung	Takeda Pharmaceuticals USA Inc	2017-04-28	Brain metastases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Ependymoma; Granuloma, Plasma Cell; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Meningioma; Myofibroma; Neoplasms; Neurilemmoma; Neurofibromatosis 2; Neuroma, Acoustic; Sarcoma, Kaposi; Solid tumours	상세
Nintedanib Esylate	BIBF-1120	Approved	C.H. Boehringer Sohn Ag & Co. Kg	Ofev, Vargatef	United States	Idiopathic Pulmonary Fibrosis	Boehringer Ingelheim International Gmbh	2014-10-15	Adenocarcinoma, Clear Cell; Appendiceal Neoplasms; Asbestosis; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Endometrial Stromal Tumors; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Mesothelioma; Multiple Myeloma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Fibrosis; Radiation Pneumonitis; Rejection of lung transplantation; Sarcoma; Scleroderma, Systemic; Silicosis; Small Cell Lung Carcinoma; Solid tumours; systemic sclerosis-associated interstitial lung disease; Telangiectasia, Hereditary Hemorrhagic; Uterine Neoplasms	상세
Vorolanib	CM-082; X-82; EYP-1901; XV-615	Approved	Tyrogenex Inc	伏美纳, DURAVYU™	Mainland China	Carcinoma, Renal Cell	Betta Pharmaceuticals Co Ltd	2023-06-07	Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Choroidal Neovascularization; Diabetic macular oedema; Diabetic Retinopathy; Eye Diseases; Gastroesophageal Junction Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Macular Degeneration; Melanoma; Neoplasms; Pancreatic Neoplasms; Retinal Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Wet Macular Degeneration	상세
Gilteritinib Fumarate	ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code)	Approved	Astellas Pharma Inc	Xospata	Japan	Leukemia, Myeloid, Acute	Astellas Pharma Inc	2018-09-21	Carcinoma, Non-Small-Cell Lung; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Renal Insufficiency; Solid tumours	상세
Pacritinib Citrate	ONX-0803; SB-1518	Approved	S*BIO Pte Ltd	VONJO, Epjevy, ENPAXIQ	United States	Primary Myelofibrosis	Sobi	2022-02-28	Bone Marrow Diseases; Carcinoma, Non-Small-Cell Lung; Castleman Disease; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Graft vs Host Disease; Hematologic Diseases; Hepatic Insufficiency; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Lymphoma; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Myelodysplastic Syndromes; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Sarcoma, Kaposi; Thrombocythemia, Essential; Thrombocytopenia; VEXAS Syndome; Waldenstrom Macroglobulinemia	상세
Fedratinib	TG-101348; SAR-302503	Approved	Sanofi	Inrebic	United States	Primary Myelofibrosis	Bristol-Myers Squibb Company	2019-08-16	Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Neutrophilic, Chronic; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Renal Insufficiency; Splenomegaly; Thrombocythemia, Essential	상세
Ponatinib Hydrochloride	AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534	Approved	Ariad	英可欣, Iclusig	United States	Leukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Ariad Pharmaceuticals Inc	2012-12-14	Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Non-Small-Cell Lung; Common Bile Duct Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Chronic; Lymphoma; Medullary thyroid cancer (MTC); Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms	상세
Sunitinib Malate	PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt	Approved	Pfizer Inc	Sutent, 索坦	United States	Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell	Cppi Cv	2006-01-26	Abdominal Neoplasms; Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenocortical Carcinoma; AIDS-Related Complex; Amyloidosis; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Barrett Esophagus; Brain metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Adenosquamous; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Choriocarcinoma; Chronic eosinophilic leukemia (CEL); Cognition Disorders; Colorectal Neoplasms; Diabetic macular oedema; Endodermal Sinus Tumor; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Fibrosarcoma; Gastrointestinal Stromal Tumors; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangi	상세
Pexidartinib	PLX-3397	Approved	Daiichi Sankyo Co Ltd	Turalio	United States	Giant Cell Tumor of Tendon Sheath	Daiichi Sankyo Inc	2019-08-02	Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumor of Tendon Sheath; Giant Cell Tumors; Glioblastoma; Hodgkin Disease; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Melanoma; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Neurofibroma, Plexiform; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular	상세
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	상세
Sorafenib Tosylate	NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085	Approved	Onyx Pharmaceuticals Inc	Nexavar, 多吉美	United States	Carcinoma, Renal Cell	Bayer Healthcare Pharmaceuticals Inc	2005-12-01	Abdominal Neoplasms; Adenocarcinoma; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Colonic Neoplasms; Esophageal Neoplasms; Facial Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gallbladder Neoplasms; Gastrinoma; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Glucagonoma; Head and Neck Neoplasms; Heart Arrest; Hemangiosarcoma; Hepatopulmonary Syndrome; Histiocytoma, Malignant Fibrous; Hypertension, Portal; Hypopharyngeal Neoplasms; Insulinoma; Kidney Diseases; Kidney Neoplasms; Laryngeal Diseases; Laryngeal Neoplasms; Leiomyosarcoma; Leukemia, Basophilic, Acute; Leukemia, Eosin	상세
Famitinib Malate	SHR-1020	Approved	Jiangsu Hengrui Medicine Co Ltd	艾比特	Mainland China	Uterine Cervical Neoplasms	Jiangsu Hengrui Medicine Co Ltd	2025-05-27	Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	상세
Midostaurin	PKC-412; PKC-412A; CGP-41231; CGP-41251	Approved	Novartis Pharma Ag	Rydapt	United States	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-Cell	Novartis Pharmaceuticals Corp	2017-04-28	Hematologic Neoplasms; Hepatic Insufficiency; Leukemia; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Mastocytosis; Mastocytosis, Systemic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세