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FKBP12

FKBP12

FKBP12 분자 정보

Molecule Name
FK506-binding protein 1A
분자 별명
FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE
Drug Development Progress
임상 약물 수5
시판 약물 수2
최고 연구 개발 단계Approved
표적 별명
Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A
분자 배경
Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

FKBP12 제품 목록

Species
  • Human（1）
Tag
  • His Tag（1）
Host
  • E. coli（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
FKBP12
FKA-H5122
Human FKBP12 / FKBP1A Protein, His Tag
Human
E. coli
SDS-PAGE

$130.00

100ug
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임상 약물 정보

영어 이름연구 코드연구 개발 단계회사적응증임상 시험
MAM-1003-1MAM-1003-1Phase 2 ClinicalMarinomed Biotech AG
Conjunctivitis, Allergic; Rhinitis, Allergic
상세
Tacrolimus (novaliq)NOV-05; NOV05; BTQ2401; BTQ-2401Phase 2 ClinicalNovaliq Gmbh
Keratoconjunctivitis; Uveitis; Uveitis, Anterior; Xerophthalmia
상세
Plerixafor/Tacrolimus HydrateMRG-001(MedRegen); AMD3100+FK506Phase 2 ClinicalMedRegen LLC
Abdominal Injuries; Amyotrophic Lateral Sclerosis; Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Hepatitis, Alcoholic; Motor Neuron Disease; Respiratory Distress Syndrome, Adult; Respiratory Insufficiency; Respiratory Tract Diseases; Wounds and Injuries
상세
RimiducidAP-1903Phase 2 ClinicalAriad Pharmaceuticals Inc, Bellicum Pharmaceuticals Inc
Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Neoplasms; Colorectal Neoplasms; Congenital Bone Marrow Failure Syndromes; Cytopenia; Fanconi Anemia; Graft vs Host Disease; Hematologic Neoplasms; Hemoglobinopathies; Hodgkin Disease; Immune System Diseases; Immunoproliferative Disorders; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Diseases; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm, Residual; Neuroblastoma; Osteopetrosis; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Immunodeficiency Diseases; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Thalassemia; Uveal melanoma
상세
SQ-708SQ-708Phase 1 ClinicalShenyang Xingqi Pharmaceutical Co Ltd
Keratoplasty rejection
상세

시판 약물 정보

영어 이름연구 코드연구 개발 단계회사가장 빠른 브랜드 이름가장 빠른 승인 국가가장 빠른 적응증가장 빠른 승인 회사가장 빠른 승인 날짜적응증임상 시험
Tacrolimus HydrateFK-506; MR-4; RTU-007; LCP-Tacro; FR-900506; L-679934; FK-506MR; FK-506EApprovedAstellas Pharma IncProtopy, Graceptor (as hydrate), TacroBell, Advagraf, Envarsus, Modigraf, Astagraf XL, Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复United StatesRejection of liver transplantation; Rejection in heart transplantation; Rejection of renal transplantationAstellas Pharma Us Inc1994-04-08
Amputation, Traumatic; Arthritis, Rheumatoid; Asthma; Bone marrow transplant rejection; Brain Death; Burns; Colitis, Ulcerative; Conjunctivitis; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Dry Eye Syndromes; Edema; Encephalitis; Genital Diseases, Male; Glomerulonephritis, IGA; Graft vs Host Disease; Hamman-Rich Syndrome; Infertility, Female; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Keratoplasty rejection; Kidney Diseases; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Failure; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Medication Adherence; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Ocular inflammation; Peripheral Nerve Injuries; Polymyositis; Primary Graft Dysfunction; Primary Myelofibrosis; Psoriasis; Pulmonary Arterial Hypertension; Rejection in heart transplantation; Rejection of renal transplantation; Rejection of liver transplantation; Rejection of lung transplantation; Rejecti
상세
PimecrolimusSDZ-​ASM-981; ASM-998; ASM-981ApprovedNovartis Pharma AgElidelUnited StatesDermatitis, AtopicBausch & Lomb (Singapore) Pvi Ltd2001-12-13
Dermatitis; Dermatitis, Atopic; Dermatitis, Perioral; Dermatitis, Seborrheic; Eczema; Exanthema; Keratoconjunctivitis Sicca; Lichen Planus, Oral; Netherton Syndrome; Pityriasis; Prurigo Nodularis; Vitiligo
상세
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