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FKBP12

FKBP12 Overview

English Name	FK506-binding protein 1A	Approved Drugs	2
Drugs in Clinical Trials	5	Target Synonym	Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A
Highest Development Stage	Approved

English Name	FK506-binding protein 1A
Target Synonym	Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A
Approved Drugs	2
Drugs in Clinical Trials	5
Highest Development Stage	Approved

FKBP12 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FKA-H5122	Human	E. coli	Human FKBP12 / FKBP1A Protein, His Tag

Total: 1

FKBP12 Background

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

FKBP12 Synonyms

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
MAM-1003-1	MAM-1003-1	Phase 2 Clinical	Marinomed Biotech AG	Conjunctivitis, Allergic; Rhinitis, Allergic	Details
Tacrolimus (novaliq)	NOV-05; NOV05; BTQ2401; BTQ-2401	Phase 2 Clinical	Novaliq Gmbh	Keratoconjunctivitis; Uveitis; Uveitis, Anterior; Xerophthalmia	Details
Plerixafor/Tacrolimus Hydrate	MRG-001(MedRegen); AMD3100+FK506	Phase 2 Clinical	MedRegen LLC	Abdominal Injuries; Amyotrophic Lateral Sclerosis; Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Hepatitis, Alcoholic; Motor Neuron Disease; Respiratory Distress Syndrome, Adult; Respiratory Insufficiency; Respiratory Tract Diseases; Wounds and Injuries	Details
Rimiducid	AP-1903	Phase 2 Clinical	Ariad Pharmaceuticals Inc, Bellicum Pharmaceuticals Inc	Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Neoplasms; Colorectal Neoplasms; Congenital Bone Marrow Failure Syndromes; Cytopenia; Fanconi Anemia; Graft vs Host Disease; Hematologic Neoplasms; Hemoglobinopathies; Hodgkin Disease; Immune System Diseases; Immunoproliferative Disorders; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Diseases; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm, Residual; Neuroblastoma; Osteopetrosis; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Immunodeficiency Diseases; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Thalassemia; Uveal melanoma	Details
SQ-708	SQ-708	Phase 1 Clinical	Shenyang Xingqi Pharmaceutical Co Ltd	Keratoplasty rejection	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Tacrolimus Hydrate	FK-506; MR-4; RTU-007; LCP-Tacro; FR-900506; L-679934; FK-506MR; FK-506E	Approved	Astellas Pharma Inc	Protopy, Graceptor (as hydrate), TacroBell, Advagraf, Envarsus, Modigraf, Astagraf XL, Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复	United States	Rejection of liver transplantation; Rejection in heart transplantation; Rejection of renal transplantation	Astellas Pharma Us Inc	1994-04-08	Amputation, Traumatic; Arthritis, Rheumatoid; Asthma; Bone marrow transplant rejection; Brain Death; Burns; Colitis, Ulcerative; Conjunctivitis; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Dry Eye Syndromes; Edema; Encephalitis; Genital Diseases, Male; Glomerulonephritis, IGA; Graft vs Host Disease; Hamman-Rich Syndrome; Infertility, Female; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Keratoplasty rejection; Kidney Diseases; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Failure; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Medication Adherence; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Ocular inflammation; Peripheral Nerve Injuries; Polymyositis; Primary Graft Dysfunction; Primary Myelofibrosis; Psoriasis; Pulmonary Arterial Hypertension; Rejection in heart transplantation; Rejection of renal transplantation; Rejection of liver transplantation; Rejection of lung transplantation; Rejecti	Details
Pimecrolimus	SDZ-ASM-981; ASM-998; ASM-981	Approved	Novartis Pharma Ag	Elidel	United States	Dermatitis, Atopic	Bausch & Lomb (Singapore) Pvi Ltd	2001-12-13	Dermatitis; Dermatitis, Atopic; Dermatitis, Perioral; Dermatitis, Seborrheic; Eczema; Exanthema; Keratoconjunctivitis Sicca; Lichen Planus, Oral; Netherton Syndrome; Pityriasis; Prurigo Nodularis; Vitiligo	Details