언어 선택

FKBP12

FKBP12 분자 정보

영어 이름	FK506-binding protein 1A	시판 약물 수	2
임상 약물 수	5	표적 별명	Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A
최고 연구 개발 단계	Approved

영어 이름	FK506-binding protein 1A
표적 별명	Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A，FK506-Binding Protein， T-Cell， 12-KD，FK506-Binding Protein 1A (12kD)，Protein Kinase C Inhibitor 2，FK506-Binding Protein 12，FK506 Binding Protein12，FK506-Binding Protein 1，FKBP12-Exip3，Calstabin 1，PPIASE，PKC12，PKCI2，Tacrolimus Binding Protein 1A，FKBP12C，FK506 Binding Protein 1A， 12kDa，12 KDa FK506-Binding Protein，Immunophilin FKBP12，12 KDa FKBP，Rotamase，FKBP Prolyl Isomerase 1A，FKBP1，FKBP12，FKBP-12，PPIase FKBP1A，FK506-binding protein 1A，Calstabin-1，FKBP-1A，FKBP1A，FK506 Binding Protein 1A
시판 약물 수	2
임상 약물 수	5
최고 연구 개발 단계	Approved

FKBP12 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
FKA-H5122	Human	E. coli	Human FKBP12 / FKBP1A Protein, His Tag

총 수량1

제품 문의

FKBP12분자 배경

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

FKBP12분자 별명

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
MAM-1003-1	MAM-1003-1	Phase 2 Clinical	Marinomed Biotech AG	Conjunctivitis, Allergic; Rhinitis, Allergic	상세
Tacrolimus (novaliq)	NOV-05; NOV05; BTQ2401; BTQ-2401	Phase 2 Clinical	Novaliq Gmbh	Keratoconjunctivitis; Uveitis; Uveitis, Anterior; Xerophthalmia	상세
Plerixafor/Tacrolimus Hydrate	MRG-001(MedRegen); AMD3100+FK506	Phase 2 Clinical	MedRegen LLC	Abdominal Injuries; Amyotrophic Lateral Sclerosis; Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Hepatitis, Alcoholic; Motor Neuron Disease; Respiratory Distress Syndrome, Adult; Respiratory Insufficiency; Respiratory Tract Diseases; Wounds and Injuries	상세
Rimiducid	AP-1903	Phase 2 Clinical	Ariad Pharmaceuticals Inc, Bellicum Pharmaceuticals Inc	Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Neoplasms; Colorectal Neoplasms; Congenital Bone Marrow Failure Syndromes; Cytopenia; Fanconi Anemia; Graft vs Host Disease; Hematologic Neoplasms; Hemoglobinopathies; Hodgkin Disease; Immune System Diseases; Immunoproliferative Disorders; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Diseases; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm, Residual; Neuroblastoma; Osteopetrosis; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Immunodeficiency Diseases; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Thalassemia; Uveal melanoma	상세
SQ-708	SQ-708	Phase 1 Clinical	Shenyang Xingqi Pharmaceutical Co Ltd	Keratoplasty rejection	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Tacrolimus Hydrate	FK-506; MR-4; RTU-007; LCP-Tacro; FR-900506; L-679934; FK-506MR; FK-506E	Approved	Astellas Pharma Inc	Protopy, Graceptor (as hydrate), TacroBell, Advagraf, Envarsus, Modigraf, Astagraf XL, Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复	United States	Rejection of liver transplantation; Rejection in heart transplantation; Rejection of renal transplantation	Astellas Pharma Us Inc	1994-04-08	Amputation, Traumatic; Arthritis, Rheumatoid; Asthma; Bone marrow transplant rejection; Brain Death; Burns; Colitis, Ulcerative; Conjunctivitis; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Dry Eye Syndromes; Edema; Encephalitis; Genital Diseases, Male; Glomerulonephritis, IGA; Graft vs Host Disease; Hamman-Rich Syndrome; Infertility, Female; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Keratoplasty rejection; Kidney Diseases; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Failure; Lung Diseases, Interstitial; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Medication Adherence; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Ocular inflammation; Peripheral Nerve Injuries; Polymyositis; Primary Graft Dysfunction; Primary Myelofibrosis; Psoriasis; Pulmonary Arterial Hypertension; Rejection in heart transplantation; Rejection of renal transplantation; Rejection of liver transplantation; Rejection of lung transplantation; Rejecti	상세
Pimecrolimus	SDZ-ASM-981; ASM-998; ASM-981	Approved	Novartis Pharma Ag	Elidel	United States	Dermatitis, Atopic	Bausch & Lomb (Singapore) Pvi Ltd	2001-12-13	Dermatitis; Dermatitis, Atopic; Dermatitis, Perioral; Dermatitis, Seborrheic; Eczema; Exanthema; Keratoconjunctivitis Sicca; Lichen Planus, Oral; Netherton Syndrome; Pityriasis; Prurigo Nodularis; Vitiligo	상세