언어 선택

FGF R3 (IIIc)

FGF R3 (IIIc) 분자 정보

영어 이름	Fibroblast growth factor receptor 3	시판 약물 수	9
임상 약물 수	30	표적 별명	Fibroblast Growth Factor Receptor 3-S，EC:2.7.10.1，EC 2.7.10，JTK4，CD333，FGFR3，Fibroblast Growth Factor Receptor 3，FGFR-3，Fibroblast Growth Factor Receptor 3 Variant 4，Achondroplasia， Thanatophoric Dwarfism，Hydroxyaryl-Protein Kinase，Tyrosine Kinase JTK4，CD333 Antigen，EC 2.7.10.1，HSFGFR3EX，CEK2，ACH，Receptor， Fibroblast Growth Factor， Type 3
최고 연구 개발 단계	Approved

영어 이름	Fibroblast growth factor receptor 3
표적 별명	Fibroblast Growth Factor Receptor 3-S，EC:2.7.10.1，EC 2.7.10，JTK4，CD333，FGFR3，Fibroblast Growth Factor Receptor 3，FGFR-3，Fibroblast Growth Factor Receptor 3 Variant 4，Achondroplasia， Thanatophoric Dwarfism，Hydroxyaryl-Protein Kinase，Tyrosine Kinase JTK4，CD333 Antigen，EC 2.7.10.1，HSFGFR3EX，CEK2，ACH，Receptor， Fibroblast Growth Factor， Type 3
시판 약물 수	9
임상 약물 수	30
최고 연구 개발 단계	Approved

FGF R3 (IIIc) 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
Fc Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
FGC-H5256	Human	HEK293	Human FGF R3 (IIIc) / FGF R3C / CD333 Protein, Fc Tag, low endotoxin (MALS verified)

총 수량1

FGF R3 (IIIc)분자 배경

Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc). Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade.

FGF R3 (IIIc)분자 별명

FGF R3 (IIIc),FGF R3C,CD333

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Infigratinib	BGJ-398 phosphate; BGJ-398; NVP-BGJ398; BBP-831; KK8398	Phase 3 Clinical	Novartis Pharma Ag	Achondroplasia; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colonic Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Hematologic Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Papillomavirus Infections; Rectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	상세
Vepugratinib	LOXO-435; LY3866288; LY-3866288; LOX-24350	Phase 3 Clinical	Eli Lilly And Company	Carcinoma, Transitional Cell; Neoplasm Metastasis; Neoplasms; Solid tumours; Ureteral Neoplasms; Urinary Bladder Neoplasms	상세
SC-0011	SC-0011	Phase 3 Clinical	Shijiazhuang Zhikang Hongren New Drug Development Co Ltd	Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms	상세
Zoligratinib	CH-5183284; FF-284; Debio-1347	Phase 2 Clinical	Chugai Pharmaceutical Co Ltd	Breast Neoplasms; Solid tumours	상세
AUR-109	ODM-203; AUR-109	Phase 2 Clinical	Orion Corp	Breast Neoplasms; Carcinoma, Renal Cell; Colorectal Neoplasms; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Pulmonary Fibrosis; Solid tumours; Urinary Bladder Neoplasms	상세
Lucitanib	S-80881; AL-3810; CO-3810; E-3810; S-80881-2	Phase 2 Clinical	Advenchen Laboratories Nanjing Ltd	Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Genital Neoplasms, Female; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thymus Neoplasms	상세
Rogaratinib	BAY-1163877	Phase 2 Clinical	Bayer AG	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Gastrointestinal Stromal Tumors; Metastatic breast cancer; Neoplasms; Sarcoma; Solid tumours; Urinary Bladder Neoplasms	상세
Fexagratinib	AZD4547; AZD-4547; ABSK-091; ABSK091	Phase 2 Clinical	Astrazeneca Plc	Adenocarcinoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Foodborne Diseases; Gastrointestinal Diseases; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphoma; Melanoma; Metastatic breast cancer; Multiple Myeloma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms	상세
Derazantinib	ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087	Phase 2 Clinical	Arqule Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Transitional Cell; Cholangiocarcinoma; Solid tumours; Stomach Neoplasms; Urogenital Neoplasms	상세
Dabogratinib	TYRA-300; TYRA300	Phase 2 Clinical	Tyra Biosciences Inc	Achondroplasia; Carcinoma; Carcinoma, Transitional Cell; Solid tumours; Urinary Bladder Neoplasms; Urologic Neoplasms	상세
Inhaled Nintedanib – dry powder (Avalyn Pharma)	AP02; AP 02 DP; AP-02; AP02-DP	Phase 2 Clinical	Avalyn Pharma Inc	Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Respiratory Tract Diseases	상세
ABSK-061	ABSK061	Phase 2 Clinical	ABbisko Therapeutics Co Ltd	Achondroplasia; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Esophageal Neoplasms; Solid tumours	상세
PZH-2111	PZH2111; PZH-2111	Phase 2 Clinical	Zhangzhou Pientzehuang Pharmaceutical Co Ltd	Cholangiocarcinoma; Solid tumours	상세
Gunagratinib	ICP-192	Phase 2 Clinical	Beijing Tiancheng Pharmaceutical Technology Co Ltd	Biliary Tract Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Head and Neck Neoplasms; Lung Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms	상세
Recifercept	PF-07256472; TA-46	Phase 1 Clinical	Pfizer Inc	Achondroplasia	상세
BPI-17509	BPI-17509	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Solid tumours	상세
HH185	3D-185; 3-D185; HH-185; 3D185	Phase 1 Clinical	ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Medicilon Inc	Solid tumours	상세
nintedanib (Avalyn Pharma)		Phase 1 Clinical	Avalyn Pharma Inc	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	상세
TYRA-200	TYRA200; TYRA-200	Phase 1 Clinical	Tyra Biosciences Inc	Bile Duct Neoplasms; Biliary Tract Neoplasms; Cholangiocarcinoma; Solid tumours	상세
ASN-8639	ASN-8639; ASN8639	Phase 1 Clinical	Asieris Pharmaceuticals Ltd	Solid tumours	상세
Nintedanib Esylate Inhalation Powder(Cspc)		Phase 1 Clinical	Cspc-Nbp Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	상세
Fibroblast growth factor receptor 3 (Eli Lilly and Company)		Phase 1 Clinical	Eli Lilly And Company	Neoplasms	상세
GR-1017	GR-1017; GQ-1011; AMB-302; BHV-1530	Phase 1 Clinical	Aimed Bio Inc, GeneQuantum Healthcare (Suzhou) Co Ltd	Carcinoma, Transitional Cell; Solid tumours	상세
TYRA-430	TYRA-430	Phase 1 Clinical	Tyra Biosciences Inc	Carcinoma, Hepatocellular; Neoplasms; Solid tumours	상세
MNKD-201	MNKD-201; MKND-201	Phase 1 Clinical	MannKind Corp	Idiopathic Pulmonary Fibrosis	상세
TYRA-300-B01	TYRA-300-B01	Phase 1 Clinical	Tyra Biosciences Inc		상세
SAR-442501	SAR-442501	Phase 1 Clinical	Sanofi	Achondroplasia; Osteochondrodysplasias	상세
TT-00434	TT-00434	Phase 1 Clinical	TransThera Sciences (Nanjing) Inc	Solid tumours; Urinary Bladder Neoplasms	상세
ABSK-121	ABSK121-NX; ABSK121	Phase 1 Clinical	ABbisko Therapeutics Co Ltd	Solid tumours	상세
CPL-304110	CPL-304110; CPL-304-110	Phase 1 Clinical	Celon Pharma Sa	Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Sarcoma; Stomach Neoplasms; Urinary Bladder Neoplasms	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Anlotinib Dihydrochloride	AL-3818	Approved	Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	福可维	Mainland China	Carcinoma, Non-Small-Cell Lung	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	2018-05-08	Bile Duct Diseases; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Colorectal Neoplasms; Craniopharyngioma; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Head and Neck Neoplasms; Hepatic Insufficiency; Leiomyosarcoma; Liver Dysfunction; Lung Diseases, Interstitial; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medullary thyroid cancer (MTC); Melanoma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Neuroendocrine Tumors; Osteoma; Ovarian Neoplasms; Peritoneal Neoplasms; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Synovial; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thoracic Neoplasms; Thyroid Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	상세
Lenvatinib Mesilate	E-7080; MK-7902; ER-203492-00	Approved	Eisai Co Ltd	Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛	United States	Thyroid Neoplasms	Eisai Inc	2015-02-13	Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Follicular; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Hepatic Insufficiency; Liver Diseases; Liver Neoplasms; Lymphoma; Melanoma; Neoplasm Metastasis; Neoplasms; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Paraganglioma; Pheochromocytoma; Renal Insufficiency; Solid tumours; Stomach Neoplasms; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Uterine Cervical Neoplasms	상세
Nintedanib Esylate	BIBF-1120	Approved	C.H. Boehringer Sohn Ag & Co. Kg	Ofev, Vargatef	United States	Idiopathic Pulmonary Fibrosis	Boehringer Ingelheim International Gmbh	2014-10-15	Adenocarcinoma, Clear Cell; Appendiceal Neoplasms; Asbestosis; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Endometrial Stromal Tumors; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Mesothelioma; Multiple Myeloma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Fibrosis; Radiation Pneumonitis; Rejection of lung transplantation; Sarcoma; Scleroderma, Systemic; Silicosis; Small Cell Lung Carcinoma; Solid tumours; systemic sclerosis-associated interstitial lung disease; Telangiectasia, Hereditary Hemorrhagic; Uterine Neoplasms	상세
Futibatinib	TAS-120	Approved	Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd	LYTGOBI	United States	Cholangiocarcinoma	Taiho Oncology Inc	2022-09-30	Biliary Tract Neoplasms; Bone Marrow Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Lymphoma; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Sarcoma; Solid tumours; Stomach Neoplasms	상세
Selpercatinib	LOXO-292; LY-3527723; ARRY-192; Ret-IN-1	Approved	Array Biopharma	Retevmo, Retsevmo, 睿妥	United States	Medullary thyroid cancer (MTC); Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung	Eli Lilly And Company	2020-05-08	Anorexia; Cachexia; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colonic Neoplasms; Ependymoma; Fibrosarcoma; Glioma; Hematologic Neoplasms; Hepatic Insufficiency; Hepatoblastoma; Histiocytosis, Langerhans-Cell; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medullary thyroid cancer (MTC); Medulloblastoma; Myofibromatosis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Poorly Differentiated Thyroid Gland Carcinoma; Renal Insufficiency; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Solid tumours; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Wilms Tumor	상세
Pemigatinib	INCB-054828; INCB-54828; IBI-375	Approved	Incyte Corp	Pemazyre, 伯坦, 达伯坦	United States	Cholangiocarcinoma	Incyte Corp	2020-04-17	Adenocarcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Bone Marrow Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colitis, Ulcerative; Colorectal Neoplasms; Endometrial Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Lung Neoplasms; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms; Translocation, Genetic; Urinary Bladder Neoplasms; Urologic Neoplasms	상세
Pazopanib Hydrochloride	GSK-786034; GW-786034B; SB-786034; GW-786034	Approved	Glaxosmithkline Plc, Novartis Pharma Ag	维全特, Armala, Votrient, Patorma	United States	Carcinoma, Renal Cell; Sarcoma	Novartis Pharma Ag	2009-10-19	Adenocarcinoma, Follicular; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Chondrosarcoma; Chondrosarcoma, Extraskeletal Myxoid; Choriocarcinoma; Colorectal Neoplasms; Dermatofibrosarcoma; Endodermal Sinus Tumor; Epistaxis; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gastrinoma; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Glucagonoma; Hemangiosarcoma; Herpes Genitalis; Herpes Simplex; HIV Infections; Hormone-Resistant Prostate Neoplasms; Insulinoma; Leiomyosarcoma; Leukemia, Myeloid, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Macular Degeneration; Medullary thyroid cancer (MTC); Melanoma; Mesothelioma; Multiple Endocrine Neoplasia T	상세
Tasurgratinib	E-7090	Approved	Eisai Co Ltd	TASFYGO	Japan	Biliary Tract Neoplasms	Eisai Co Ltd	2024-09-24	Biliary Tract Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Hepatic Insufficiency; Neoplasms; Solid tumours	상세
Erdafitinib	890E37NHMV; G-024; JNJ-493; JNJ-42756493; TAR-210	Approved	Astex Pharmaceuticals Inc	Balversa, 博珂	United States	Carcinoma, Transitional Cell	Janssen Biotech Inc	2019-04-12	Adenocarcinoma; Bile Duct Neoplasms; Bone metastases; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Ependymoma; Esophageal Neoplasms; Glioma; Hepatic Insufficiency; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Metastatic breast cancer; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile	상세