언어 선택

Fas Ligand

Fas Ligand 분자 정보

영어 이름	Soluble Fas ligand	시판 약물 수	0
임상 약물 수	3	표적 별명	CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necrosis Factor Ligand 1A
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Soluble Fas ligand
표적 별명	CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necrosis Factor Ligand 1A
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 2 Clinical

Fas Ligand 제품 목록

속성
Protein (2)
제품 라이브러리
온라인 (2)
종
Human (1)Cynomolgus / Rhesus macaque (1)
태그
His Tag (2)
마커
Unconjugated (2)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
FAL-H5241	Human	HEK293	Human Fas Ligand / TNFSF6 Protein, His Tag, premium grade
FAL-H5246	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade

총 수량2

Fas Ligand분자 배경

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Fas Ligand분자 별명

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Asunercept	CAN-008; APG-101	Phase 2 Clinical	Apogenix Gmbh	Coronavirus Disease 2019 (COVID-19); Eye Diseases; Glioblastoma; Hematologic Neoplasms; Myelodysplastic Syndromes; Skin Diseases; Solid tumours	상세
Xelafaslatide	ONL-1204	Phase 2 Clinical	Onl Therapeutics	Geographic Atrophy; Glaucoma, Open-Angle; Macular Degeneration; Retinal Detachment	상세
M3T01	M3T01	Phase 1 Clinical	Providence Health & Services	Solid tumours	상세