언어 선택

ErbB3

ErbB3 분자 정보

영어 이름	Receptor tyrosine-protein kinase erbB-3	시판 약물 수	2
임상 약물 수	31	표적 별명	EC:2.7.10.1，FERLK，EC 2.7.10，Proto-oncogene-like protein c-ErbB-3，HER3，ERBB3，Erb-B2 Receptor Tyrosine Kinase 3，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3，Tyrosine Kinase-Type Cell Surface Receptor HER3，Human Epidermal Growth Factor Receptor 3，Lethal Congenital Contracture Syndrome 2，Receptor Tyrosine-Protein Kinase ErbB-3，EC 2.7.10.1，P180-ErbB3，P45-SErbB3，P85-SErbB3，MDA-BF-1，C-ErbB-3，C-ErbB3，ErbB3-S，ErbB-3，LCCS2，Receptor， ErbB-3
최고 연구 개발 단계	Approved

영어 이름	Receptor tyrosine-protein kinase erbB-3
표적 별명	EC:2.7.10.1，FERLK，EC 2.7.10，Proto-oncogene-like protein c-ErbB-3，HER3，ERBB3，Erb-B2 Receptor Tyrosine Kinase 3，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3，Tyrosine Kinase-Type Cell Surface Receptor HER3，Human Epidermal Growth Factor Receptor 3，Lethal Congenital Contracture Syndrome 2，Receptor Tyrosine-Protein Kinase ErbB-3，EC 2.7.10.1，P180-ErbB3，P45-SErbB3，P85-SErbB3，MDA-BF-1，C-ErbB-3，C-ErbB3，ErbB3-S，ErbB-3，LCCS2，Receptor， ErbB-3
시판 약물 수	2
임상 약물 수	31
최고 연구 개발 단계	Approved

ErbB3 제품 목록

속성
Protein (8)Cell (1)
제품 라이브러리
온라인 (9)
종
Human (7)Mouse (1)Cynomolgus/Rhesus macaque (1)
태그
His Tag (4)Fc Tag (1)Strep Tag (1)Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)- (1)
마커
Unconjugated (6)FITC Labeled (1)Biotin-labeled (1)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT ER3-H5223	Human	HEK293	Human ErbB3 / Her3 Protein, His Tag (MALS verified)
HOT ER3-H5257	Human	HEK293	Human ErbB3 / Her3 Protein, Mouse IgG2a Fc Tag (MALS verified)
HOT ER3-H5259	Human	HEK293	Human ErbB3 / Her3 Protein, Fc Tag (MALS verified)
HOT ER3-H82E6	Human	HEK293	Biotinylated Human ErbB3 / Her3 Protein, His,Avitag™ (MALS verified)
HOT ER3-M52H5	Mouse	HEK293	Mouse ErbB3 / Her3 Protein, His Tag (MALS verified)
CHEK-ATP149	Human	HEK293	HEK293/Human ErbB3 Stable Cell Line
ER3-H5288	Human	HEK293	Human ErbB3 / Her3 Protein, Twin-Strep Tag (MALS verified)
ER3-HF2H5	Human	HEK293	FITC-Labeled Human ErbB3 / Her3 Protein, His Tag
ER3-C52H3	Cynomolgus/Rhesus macaque	HEK293	Cynomolgus/Rhesus macaque ErbB3 / Her3 Protein, His Tag (MALS verified)

총 수량9

ErbB3분자 배경

ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

ErbB3분자 별명

ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Izalontamab	SI-B001; SI-1X6.4	Phase 3 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Neoplasms, Glandular and Epithelial; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
JSKN-016	JSKN-016; JSKN016	Phase 3 Clinical	Jiangsu Alphamab Biopharmaceuticals Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastroesophageal Junction Neoplasms; Metastatic breast cancer; Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
YL-202	YL-202; BNT326	Phase 3 Clinical	MediLink Therapeutics Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	상세
SHR-A2009	SHR-A2009	Phase 3 Clinical	Suzhou Suncadia Biopharmaceuticals Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Solid tumours; Triple Negative Breast Neoplasms	상세
Patritumab Deruxtecan	U3-1402; U3-1402a; MK-1022	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Metastatic breast cancer; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	상세
Nezutatug	HMBD-001	Phase 2 Clinical	Hummingbird Bioscience	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	상세
Sapitinib	AZD-8931	Phase 2 Clinical	Astrazeneca Plc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms	상세
Allitinib Tosylate	AST-6; ALS-1306; AST-1306	Phase 2 Clinical	Shanghai Allist Pharmaceutical Technology Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung	상세
HMBD-501	ENV-501; HMBD-501; ENV-ONC-501	Phase 2 Clinical	Hummingbird Bioscience	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Skin Melanoma	상세
JS-212	JS212; JS-212	Phase 2 Clinical	Shanghai Junshi Biosciences Co Ltd	Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Solid tumours	상세
DB-1418	AVZO-1418; DB-1418	Phase 2 Clinical	Duality Biologics (Suzhou) Co Ltd	Lung Neoplasms; Neoplasms, Glandular and Epithelial; Solid tumours	상세
89Zr-Patritumab deruxtecan		Phase 2 Clinical	Daiichi Sankyo Co Ltd, Daiichi Sankyo Inc, The Netherlands Cancer Institute	Carcinoma, Non-Small-Cell Lung	상세
IBI-133	IBI133; IBI-133	Phase 2 Clinical		Solid tumours	상세
DB-1310	DB-1310	Phase 2 Clinical	Duality Biologics (Shanghai) Co Ltd, Duality Biologics (Suzhou) Co Ltd	Neoplasm Metastasis; Solid tumours	상세
SIBP-03	SIBP-03	Phase 2 Clinical	Shanghai Institute of Biological Products Co Ltd	Neoplasms; Squamous Cell Carcinoma of Head and Neck	상세
JK-07 (SalubrisBio)	JK07; SAL007; SAL-007	Phase 2 Clinical	Salubris Biotherapeutics Inc	Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Pulmonary Arterial Hypertension	상세
Recombinat humanized HER3-targeting antibody		Phase 2 Clinical	Shanghai Institute of Biological Products Co Ltd	Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
Elgemtumab	NOV-6; LJM-716	Phase 1 Clinical	Morphosys Ag, Novartis Pharma Ag	Breast Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	상세
MP-0274	DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274	Phase 1 Clinical	Molecular Partners Ag	Neoplasms	상세
AV-203	AV-203; CAN-017	Phase 1 Clinical	Aveo	Neoplasms; Solid tumours	상세
HDM-2024	HDM2024; HDM-2024	Phase 1 Clinical	Hangzhou Zhongmei Huadong Pharmaceutical Co Ltd	Solid tumours	상세
KHN-922	KHN-922	Phase 1 Clinical	Chengdu Kanghong Pharmaceutical Group Co Ltd	Neoplasms; Solid tumours	상세
Sirotinib Maleate	XZP-5491	Phase 1 Clinical	Shandong Xuanzhu Pharmaceutical Technology Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Stomach Neoplasms	상세
PM1300	PM-1300; PM1300	Phase 1 Clinical		Neoplasms	상세
AK-138-D-1	AK138D1; AK-138-D-1	Phase 1 Clinical		Neoplasms; Solid tumours	상세
BL-B16D1	BLB16D1; BL-B16D1	Phase 1 Clinical	Baili-Bio (Chengdu) Pharmaceutical Co Ltd, Sichuan Baili Pharmaceutical Co Ltd	Breast Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
SYS-6023	SYS-6023; SYS6023	Phase 1 Clinical	Jushi Biopharmaceutical Co Ltd	Breast Neoplasms; Metastatic breast cancer; Solid tumours	상세
AMT-562	AMT-562	Phase 1 Clinical	Multitude Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Solid tumours; Stomach Neoplasms	상세
SIBP-A13	SIBP-A13	Phase 1 Clinical	Shanghai Institute of Biological Products Co Ltd	Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Metastatic breast cancer; Solid tumours	상세
Recombinant human ErbB3 fragment vaccine (Zensun)	rhErbB3-f	Phase 1 Clinical	Zensun (Shanghai) Sci&Tech Co Ltd	Neoplasms	상세
DM-002	DM-002; DM002 (Danma)	Phase 1 Clinical	Danma (Suzhou) Biomedical Technology Co Ltd	Colorectal Neoplasms; Endometrial Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Solid tumours	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Osimertinib Mesylate	AZD-9291; RDL94R2A16; AZD-9291 Mesylate; AZD9291	Approved	Astrazeneca Plc	泰瑞沙, Tagrisso	United States	Carcinoma, Non-Small-Cell Lung	Astrazeneca Pharmaceutical Co Ltd	2015-11-13	Adenocarcinoma; Adenocarcinoma of Lung; Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphoma; Melanoma; Meningeal Neoplasms; Multiple Myeloma; Neoplasm, Residual; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms	상세
Zenocutuzumab	MCLA-128	Approved	Merus Nv	Bizengri	United States	Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung	Merus Nv	2024-12-04	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours	상세