언어 선택

EphA4

EphA4 분자 정보

영어 이름	Erythropoietin-producing hepatocellular receptor A4	시판 약물 수	0
임상 약물 수	3	표적 별명	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
최고 연구 개발 단계	Phase 1 Clinical

영어 이름	Erythropoietin-producing hepatocellular receptor A4
표적 별명	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 1 Clinical

EphA4 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
EP4-H52H8	Human	HEK293	Human EphA4 Protein, His Tag

총 수량1

EphA4분자 배경

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4분자 별명

EphA4,HEK8,SEK,TYRO1,EK8

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
ORT-247	ORT247; ORT-247	Phase 1 Clinical	Orthogonal Neuroscience Inc	Amyotrophic Lateral Sclerosis	상세
mEphA4-Fc	mEphA4-Fc	Phase 1 Clinical	Queensland Brain Institute	Amyotrophic Lateral Sclerosis; Nerve Degeneration; Nervous System Diseases	상세
E2025	E-2025; E2025	Phase 1 Clinical	Eisai Inc	Alzheimer Disease	상세